小剂量泼尼松联合他克莫司治疗老年膜性肾病疗效观察

Efficacy of Low-Dose Prednisone Combined with Tacrolimus on Elderly Membranous Nephropathy

目的探讨小剂量泼尼松联合他克莫司治疗老年膜性肾病的临床疗效,以及对患者氧化应激和肾功能指标的影响。方法选取医院肾内科2021年1月至2023年6月收治的老年膜性肾病患者50例,按随机数字表法分为观察组和对照组,各25例。对照组患者予他克莫司治疗,观察组患者在对照组治疗基础上加用小剂量泼尼松,两组均持续治疗6个月。结果观察组总有效率为92.00%,显著高于对照组的68.00%(P<0.05)。观察组患者的血清肌酐(SCr)、血尿素氮(BUN)、24 h尿蛋白定量(24 hUTP)均显著低于对照组(P<0.05),肾小球滤过率(eGFR)、超氧化物歧化酶(SOD)均显著高于对照组(P<0.05)。结论小剂量泼尼松联合他克莫司治疗老年膜性肾病疗效好,可改善患者的氧化应激和肾功能指标。

Objective To investigate the clinical efficacy of low-dose prednisone combined with tacrolimus in the treatment of elderly membranous nephropathy,and its effects on oxidative stress and renal function indicators.Methods A total of 50 elderly patients with membranous nephropathy admitted to the nephrology department of the hospital from January 2021 to June 2023 were randomly divided into the observation group and the control group by the random number table method,with 25 cases in each group.The control group was treated with tacrolimus,while the observation group received low-dose prednisone in addition to the control group.Both groups were treated continuously for 6 months.Results The total effective rate in the observation group was 92.00%,which was significantly higher than 68.00%in the control group(P<0.05).The serum creatinine(SCr),blood urea nitrogen(BUN),and 24 h urinary protein quantification(24 hUTP)in the observation group were significantly lower than those in the control group(P<0.05),while the glomerular filtration rate(eGFR)and superoxide dismutase(SOD)were significantly higher than those in the control group(P<0.05).Conclusion The combination of low-dose prednisone and tacrolimus is effective in treating elderly membranous nephropathy,and can improve oxidative stress and renal function indicators in patients.