阿托伐他汀联合氯沙坦钾治疗原发性高血压疗效观察

Efficacy of Atorvastatin Combined with Losartan Potassium in the Treatment of Primary Hypertension

目的探讨阿托伐他汀联合氯沙坦钾治疗原发性高血压患者的临床疗效。方法选择医院2019年10月至2021年3月收治的原发性高血压患者75例,随机分为对照组(37例,氯沙坦钾)与观察组(38例,氯沙坦钾联合阿托伐他汀),均治疗1个月,随访1年。结果与对照组比较,观察组收缩压、舒张压,总胆固醇、甘油三酯、低密度脂蛋白胆固醇水平显著降低,高密度脂蛋白胆固醇水平显著升高(P<0.05);观察组治疗后血小板凝聚率、血浆黏度显著降低(P<0.05)。观察组冠心病发生率为2.63%,显著低于对照组的16.22%(P<0.05)。结论阿托伐他汀联合氯沙坦钾治疗原发性高血压,降压、调脂和降低血流黏度效果明显,可预防其他心血管疾病发生。

Objective To investigate the clinical efficacy of atorvastatin combined with losartan potassium in the treatment of patients with primary hypertension.Methods A total of 75 patients with primary hypertension admitted to the hospital from October 2019 to March 2021 were seleced and randomly divided into the control group(37 cases,treated with losartan potassium)and the observation group(38 cases,treated with losartan potassium combined with atorvastatin).Both groups were treated for one month and followed up for one year.Results Compared with those in the control group,the systolic and diastolic blood pressure,total cholesterol,triglycerides,and low-density lipoprotein cholesterol levels in the observation group significant decreased,while the high-density lipoprotein cholesterol level in the observation group significant increased(P<0.05).After treatment,the platelet aggregation rate and plasma viscosity in the observation group significantly reduced(P<0.05).The incidence of coronary heart disease in the observation group was 2.63%,which was significantly lower than 16.22%in the control group(P<0.05).Conclusion Atorvastatin combined with losartan potassium in the treatment of patients with primary hypertension has a significant effect on blood pressure reduction,lipid regulation,and blood flow viscosity reduction,and can prevent the occurrence of other cardiovascular diseases.