摘要
铁死亡是近年来新发现的一种区别于凋亡的细胞死亡形式,以细胞内铁的累积和脂质过氧化水平增加为主要特征。肿瘤细胞对铁死亡的抵抗会促进肿瘤的发生发展;多种化合物能通过触发铁死亡来影响肿瘤进展。铁死亡存在复杂的调控机制,而线粒体作为铁的储存中心与代谢中心,对铁死亡起重要的调控作用。本文就铁死亡及其三个阶段、线粒体对铁死亡的调控机制以及铁死亡在肿瘤发生发展与治疗中的作用做一综述。
Ferroptosis is a recently discovered form of cell death that is distinct from apoptosis,characterized primarily by the accumulation of intracellular iron and increased levels of lipid peroxidation.Resistance of tumor cells to ferroptosis can promote tumorigenesis and tumor progression.Various compounds can influence tumor development by triggering ferroptosis.Ferroptosis involves complex regulatory mechanisms,with mitochondria serving as both an iron storage and metabolic center,playing a crucial regulatory role in ferroptosis.This review discusses ferroptosis and its three stages and the role of ferroptosis in tumorigenesis,progression,and treatment,as well as the regulatory mechanisms of mitochondria in ferroptosis.
作者
张展瑞
刘红雨
陈军
Zhanrui ZHANG;Hongyu LIU;Jun CHEN(Department of Thoracic Surgery,First Affiliated Hospital,School of Medicine,Shihezi University,Shihezi 832003,China;Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment,Tianjin Lung Cancer Institute;Department of Lung Cancer Surgery,Tianjin Medical University General Hospital,Tianjin 300052,China)
出处
《中国肺癌杂志》
CAS
CSCD
北大核心
2024年第10期785-791,共7页
Chinese Journal of Lung Cancer
基金
国家自然科学基金项目(No.82072595、No.82473191)
天津市医学重点学科(特色)建设项目(No.TJYXZDXK-061B)
天津市自然基金重点项目(No.23JCZDJC00710)
天津市卫生科技项目(No.TJWJ2022XK005)
北京市科技创新医学发展基金项目(No.KC2023-JX-0288-PZ78)资助。