脊神经射频联合免疫三氧血回输治疗带状疱疹相关性疼痛

Spinal Nerve Radiofrequency Combined with Immune Trioxy Blood Transfusion in the Treatment of Herpes Zoster Related Pain

目的:探究脊神经射频联合免疫三氧血回输治疗带状疱疹相关性疼痛的临床效果。方法:选择2018年6月—2023年6月东莞东华医院收治的120例带状疱疹相关性疼痛患者,根据随机数字表法分为对照组和观察组,各60例。对照组进行脊神经射频治疗,观察组则进行脊神经射频联合免疫三氧血回输治疗。比较两组治疗总有效率、并发症发生率、治疗前后的疼痛程度[视觉模拟评分法(VAS)评分]、疼痛因子[降钙素基因相关肽(CGRP)、P物质(SP)、前列腺素E2(PGE2)]及T淋巴细胞亚群(CD3^(+)、CD8^(+)及CD4^(+)/CD8^(+))。结果:观察组治疗总有效率显著高于对照组,并发症总发生率显著低于对照组(P<0.05)。治疗前,两组VAS评分、疼痛因子及T淋巴细胞亚群比较,差异均无统计学意义(P>0.05);治疗1、3、7 d后,观察组VAS评分构成均优于对照组,疼痛因子均显著低于对照组,差异均有统计学意义(P<0.05)。治疗10、20 d后,观察组CD8^(+)均低于对照组,CD3^(+)及CD4^(+)/CD8^(+)均高于对照组,差异均有统计学意义(P<0.05)。结论:脊神经射频联合免疫三氧血回输治疗带状疱疹相关性疼痛的临床效果相对较好,可有效控制患者的疼痛程度及调控机体免疫,因此在带状疱疹相关性疼痛患者中的应用价值较高。

Objective:To explore the clinical effect of spinal nerve radiofrequency combined with immune trioxy blood transfusion in the treatment of herpes zoster related pain.Method:A total of 120 patients with herpes zoster related pain admitted to Dongguan Donghua Hospital from June 2018 to June 2023 were selected and divided into control group and observation group according to random number table method,with 60 cases in each group.The control group received spinal nerve radiofrequency,and the observation group received spinal nerve radiofrequency combined with immune trioxy blood transfusion.The total response rate,complication rate,pain degree[visual analogue scale(VAS)score],pain factors[calcitonin gene-related peptide(CGRP),substance P(SP)and prostaglandin E2(PGE2)]and T lymphocyte subsets(CD3^(+),CD8^(+)and CD4^(+)/CD8^(+))before and after treatment were compared between the two groups.Result:The total effective rate of the observation group was significantly higher than that of the control group,and the total complication rate was significantly lower than that of the control group(P<0.05).Before treatment,there were no statistically significant differences in VAS score,pain factor and T lymphocyte subsets between the two groups(P>0.05).After 1,3 and 7 d of treatment,composition of VAS scores results were better than those in control group,and pain factors in observation group were significantly lower than those in control group,the differences were statistically significant(P<0.05).After 10 and 20 d of treatment,CD8^(+)in observation group were significantly lower than those in control group,and CD3^(+)and CD4^(+)/CD8^(+)were significantly higher than those in control group,the differences were statistically significant(P<0.05).Conclusion:Spinal nerve radiofrequency combined with immune trioxy blood transfusion has relatively good clinical effect in the treatment of herpes zoster related pain,which can effectively control the pain degree of patients and regulate the body's immunity,so it has high application value in patients with herpes zoster related pain.