阿比多尔联合开喉剑喷雾剂治疗手足口病的临床研究

Clinical Study of Arbidol Combined with Kaihoujian Spray in the Treatment of Hand Foot Mouth Disease

目的:探讨阿比多尔联合开喉剑喷雾剂治疗手足口病的临床效果。方法:选择2023年3月—2024年1月在东莞市桥头医院儿科就诊的100例手足口病患儿作为研究对象,随机分为观察组(n=50)和对照组(n=50)。观察组给予阿比多尔联合开喉剑喷雾剂及对症治疗,对照组给予阿比多尔及对症治疗。观察患儿体温恢复时间、口腔溃疡及皮肤疱疹消退时间、口腔疼痛改善时间,比较两组柯萨奇病毒A16型(CoxA16)抗体、肠道病毒71型(EV71)抗体阳性率和血常规、肝肾功能、空腹血糖、C反应蛋白(CRP)、心肌肌钙蛋白I(cTnI)、降钙素原(PCT),以及治疗效果。结果:观察组体温恢复时间、口腔溃疡及皮肤疱疹消退时间、口腔疼痛改善时间均早于对照组,差异均有统计学意义(P<0.05)。治疗后,观察组CoxA16抗体、EV71抗体阳性率均低于对照组,差异均有统计学意义(P<0.05)。观察组治疗后的白细胞计数、中性粒细胞、CRP、PCT均低于对照组,差异均有统计学意义(P<0.05)。观察组总有效率显著高于对照组(96.00%vs 74.00%),差异有统计学意义(P<0.05)。结论:阿比多尔联合开喉剑喷雾剂治疗手足口病,能有效缩短病程,减轻症状,提高治疗效果。

Objective:To investigate the clinical effect of Arbidol combined with Kaihoujian Spray in the treatment of hand foot mouth disease.Method:A total of 100 children with hand foot mouth disease treated in Department of Paediatrics,Dongguan Qiaotou Hospital from March 2023 to January 2024 were selected as the study objects,and randomly divided into observation group(n=50)and control group(n=50).The observation group was given Arbidol combined with Kaihoujian Spray and symptomatic treatment,and the control group was given Arbidol and symptomatic treatment.The recovery time of children's body temperature,the regression time of oral ulcer and skin herpes,and the improvement time of oral pain were observed.The positive rates of Coxsackie virus A16(CoxA16)antibody and enterovirus 71(EV71)antibody,blood routine,liver and kidney function,fasting blood glucose,C reactive protein(CRP),cardiac troponin I(cTnI),procalcitonin(PCT)and treatment effect were compared between the two groups.Result:The recovery time of body temperature,the regression time of oral ulcer and skin herpes and the improvement time of oral pain in the observation group were earlier than those in the control group,the differences were statistically significant(P<0.05).After treatment,the positive rates of CoxA16 antibody and EV71 antibody in observation group were lower than those in control group,the differences were statistically significant(P<0.05).After treatment,the white blood cell count,neutrophils,CRP and PCT in observation group were lower than those in control group,the differences were statistically significant(P<0.05).The total effective rate of the observation group was significantly higher than that of the control group(96.00%vs 74.00%),the difference was statistically significant(P<0.05).Conclusion:Arbidol combined with Kaihoujian Spray in the treatment of hand foot mouth disease can effectively shorten the course of disease,relieve symptoms and improve the therapeutic effect.