针对性护理干预用于非小细胞肺癌化疗患者对其癌因性疲乏和不良反应的影响

Effect of Targeted Nursing Intervention on Cancer-related Fatigue and Adverse Reactions in Patients with Non-small Cell Lung Cancer Undergoing Chemotherapy

目的:分析针对性护理干预对非小细胞肺癌(NSCLC)化疗患者癌因性疲乏和不良反应的影响。方法:前瞻性选取九江市第三人民医院2022年6月—2023年6月90例NSCLC患者进行随机对照试验,均采用含铂双药化疗,按随机数字表法分为对照组和观察组,各45例。予以对照组常规护理,予以观察组常规护理+针对性护理。于护理前后分别应用焦虑自评量表(self-rating anxiety scale,SAS)与抑郁自评量表(self-rating depression scale,SDS)、Piper疲乏调查量表(PFS)、生活质量综合评定量表(GQOLI-74)评价两组的心理健康状况、癌因性疲乏程度和生活质量;护理期间,参照美国癌症研究所化疗毒副作用分级标准评价两组骨髓抑制、消化道反应等毒副反应分级情况。结果:护理后,两组SAS、SDS和PFS各维度评分均较护理前降低,且观察组均低于对照组(P<0.05)。护理期间,与对照组相比,观察组骨髓抑制、消化道反应、皮肤黏膜损伤和过敏反应均轻(P<0.05)。护理后,两组GQOLI-74评分均较护理前升高,且观察组高于对照组(P<0.05)。结论:针对性护理可改善NSCLC患者心理健康状况,减轻癌因性疲乏,降低毒副反应分级,并提高患者生活质量。

Objective:To analyze the effect of targeted nursing interventions on cancer-related fatigue and adverse reactions in chemotherapy patients with non-small cell lung cancer(NSCLC).Method:A prospective randomized controlled trial was conducted on 90 NSCLC patients from Jiujiang Third People's Hospital from June 2022 to June 2023,all of whom received platinum containing dual drug chemotherapy.They were divided into control group and observation group by random number table method,45 cases in each group.The control group was given routine nursing,and the observation group was given routine nursing+targeted nursing.Before and after nursing,self-rating anxiety scale(SAS)and self-rating depression scale(SAS),Piper fatigue scale(PFS),and generic quality of life inventory-74(GQOLI-74)were used to evaluate the psychological health status,cancer-related fatigue level,and quality of life of the two groups.During the nursing period,evaluate the classification of toxic side effects such as bone marrow suppression and gastrointestinal reactions in the two groups according to the classification criteria of chemotherapy toxicity and side effects by the american cancer institute.Result:After nursing,the SAS,SDS and PFS scores in all dimensions of both groups were lower than those before nursing,and those of the observation group were lower than those of the control group(P<0.05).During the nursing period,compared with the control group,the bone marrow suppression,gastrointestinal reaction,skin mucosal injury and allergic reaction in the observation group were lighter(P<0.05).After nursing,the GQOLI-74 scores in both groups were higher than those before nursing,and the observation group was higher than that of the control group(P<0.05).Conclusion:Targeted nursing can improve the mental health status of NSCLC patients,reduce cancer-related fatigue,lower the grading of toxic side effects,and improve their quality of life.