黏膜下注射血凝酶在内镜下结直肠息肉冷圈套器切除术中预防术中出血的效果

Effect of Submucosal Hemagglutinin Injection in the Prevention of Intraoperative Bleeding during Endoscopic Cold Snare Resection of Colorectal Polyps

目的:探究黏膜下注射血凝酶在内镜下结直肠息肉冷圈套器切除术中预防术中出血的效果。方法:选取2022年11月—2023年12月宜春学院第二附属医院内科收治的80例行内镜下结直肠息肉冷圈套器切除术患者作为研究对象,共90枚息肉,采用计算机随机分配法分为观察组(n=40,48枚息肉)和对照组(n=40,42枚息肉)。两组均采用内镜下结直肠息肉冷圈套器切除术治疗,对照组于黏膜下注射无菌生理盐水+肾上腺素,观察组于黏膜下注射无菌生理盐水+肾上腺素+血凝酶预防出血。比较两组术中出血量、止血时间、手术结束时间、息肉切除时间、息肉完整切除率、并发症。结果:观察组术中出血量少于对照组,止血时间、手术结束时间均短于对照组(P<0.05)。两组息肉完整切除率比较,差异均无统计学意义(P>0.05),观察组息肉切除时间短于对照组(P<0.05)。观察组并发症总发生率低于对照组(P<0.05)。结论:内镜下结直肠息肉冷圈套器切除术采用黏膜下注射血凝酶止血效果显著,能减少术中出血量,缩短止血时间及手术结束时间,减少术后并发症,提升手术安全性,适合临床应用。

Objective:To investigate the effect of submucosal Hemagglutinin injection on the prevention of intraoperative bleeding during endoscopic cold snare resection of colorectal polyps.Method:A total of 80 patients with endoscopic cold snare resection of colorectal polyps admitted to Department of Internal Medicine of the Second Affiliated Hospital of Yichun University from November 2022 to December 2023 were selected as the study objects,a total of 90 polyps.They were divided into observation group(n=40,48 polyps)and control group(n=40,42 polyps)by computer random allocation method.Endoscopic cold snare resection of colorectal polyps was performed in both groups.The control group was given submucosal injection of sterile normal saline+Epinephrine,and the observation group was given submucosal injection of sterile normal saline+Epinephrine+Hemagglutinin to prevent hemostasis.The amount of blood loss during operation,hemostasis time,operation end time,polyp removal time,complete polyp removal rate and complications were compared between the two groups.Result:The amount of blood loss during operation in the observation group was less than that in the control group,the time of hemostasis and the time of end of operation were shorter than those in the control group(P<0.05).There was no statistical significance in complete polyp removal rate between groups(P>0.05).The time of polypectomy in observation group was shorter than that in control group(P<0.05).The total complication rate of observation group was lower than that of control group(P<0.05).Conclusion:During endoscopic cold snare resection of colorectal polyps,the use of submucosal Hemthrombin injection has significant hemostasis effect,which can reduce intraoperative blood loss,shorten the hemostasis time and operation end time,reduce postoperative complications,and improve surgical safety,which is suitable for clinical application.