皮下胰岛素泵与多次胰岛素皮下注射治疗2型糖尿病的效果对比

Comparison of the Efficacy of Subcutaneous Insulin Pump and Multiple Subcutaneous Insulin Injection in the Treatment of Type 2 Diabetes Mellitus

目的:探究皮下胰岛素泵与多次胰岛素皮下注射治疗2型糖尿病的效果。方法:选取新余市人民医院内分泌科2022年5月—2023年4月80例2型糖尿病患者,随机分为两组,各40例。对照组采用长效胰岛素+速效胰岛素一日多次胰岛素注射,研究组采用皮下胰岛素泵治疗。比较两组患者治疗前、治疗6 d后血糖控制情况、日均高血糖持续时间、日均血糖波动范围、治疗情况(低血糖发生率、胰岛素用量、控制血糖达标时间)。结果:治疗后两组各餐前与餐后2 h、睡前血糖水平与平均值均显著降低,差异均有统计学意义(P<0.05);但治疗前后两组各餐前与餐后2 h、睡前、血糖水平与平均值差异均无统计学意义(P>0.05);治疗前两组日均高血糖持续时间、日均血糖波动范围差异均无统计学意义(P>0.05),治疗后研究组日均高血糖持续时间、日均血糖波动范围均低于对照组,差异均有统计学意义(P<0.05);治疗后研究组低血糖发生率低于对照组,每天胰岛素用量少于对照组,控制血糖达标时间早于对照组,差异均有统计学意义(P<0.05)。结论:两种方法均能较好降低2型糖尿病患者血糖水平,但相较于多次胰岛素皮下注射,皮下胰岛素泵治疗可减少胰岛素用量,缩短血糖达标时间,降低低血糖发生率,并更好地控制血糖波动。

Objective:To explore the therapeutic effect of subcutaneous insulin pump and multiple subcutaneous Insulin injection on type 2 diabetes mellitus.Method:A total of 80 patients with type 2 diabetes mellitus in the Department of Endocrinology of Xinyu People's Hospital from May 2022 to April 2023 were selected and randomly divided into two groups,40 cases in each group.The control group was treated with long-acting Insulin+rapid-acting Insulin injection multiple times a day,and the study group was treated with subcutaneous insulin pump.The blood glucose control,duration of daily average hyperglycemia,range of daily average blood glucose fluctuation before treatment and 6 days after treatment,and treatment(incidence of hypoglycemia,insulin dosage,and time to control blood glucose to standard)were compared between the two groups.Result:After treatment,the blood glucose level and average value of the two groups were significantly reduced before and 2 h after meals,before bedtime,the differences were statistically significant(P<0.05).However,there were no significant differences between the two groups before and after each meal,2 h after each meal,before going to bed,blood glucose level and the mean value(P>0.05).Before treatment,the average daily hyperglycemia duration and average daily blood sugar fluctuation range of the two groups had no statistical significance(P>0.05).After treatment,the average daily hyperglycemia duration and average daily blood sugar fluctuation range of the study group were lower than those of the control group,with statistical significance(P<0.05).After treatment,the incidence of hypoglycemia in the study group was lower than that in the control group,the daily insulin dosage was less than that in the control group,and the time to reach the blood glucose standard was earlier than that in the control group,the differences were statistically significant(P<0.05).Conclusion:Both methods can effectively reduce the blood glucose level in diabetic patients,but compared with multiple subcutaneous Insulin injections,subcutaneous insulin pump treatment can reduce the amount of Insulin,shorten the time of blood glucose compliance,reduce the incidence of hypoglycemia and better control blood glucose fluctuations.