吡拉西坦联合丁苯酞双序贯疗法对缺血性脑卒中伴发认知障碍的疗效研究

Efficacy of Piracetam Combined with Butylphthalide Double Sequential Therapy for Ischemic Stroke with Cognitive Impairment

目的:探究与分析吡拉西坦联合丁苯酞双序贯疗法对缺血性脑卒中伴发认知障碍的疗效。方法:选取龙岩市第二医院神经内科2022年2月—2023年9月收治的缺血性脑卒中伴发认知障碍的患者92例,按照随机数字表法分为对照组与观察组,每组46例。对照组采用丁苯酞治疗,观察组采用吡拉西坦联合丁苯酞双序贯疗法,比较两组临床疗效、治疗前后国立卫生研究院卒中量表(NIHSS)评分及Barthel指数(BI),同时比较两组不良反应发生情况。结果:观察组总有效率高于对照组(P<0.05);治疗后,观察组NIHSS评分低于对照组,BI高于对照组,差异均有统计学意义(P<0.05)。两组各不良反应发生率比较,差异均无统计学意义(P>0.05)。结论:吡拉西坦联合丁苯酞双序贯疗法治疗缺血性脑卒中伴发认知障碍可获得突出的临床效果,患者神经功能缺损情况得到了明显的改善,其日常生活能力也会有所提升,安全性较高。

Objective:To explore and analyze the effect of Piracetam combined with Butylphthalide double sequential therapy on ischemic stroke with cognitive impairment.Method:Ninety-two patients with ischemic stroke complicated with cognitive impairment admitted to the Department of Neurology,the Second Hospital of Longyan from February 2022 to September 2023 were selected and divided into control group and observation group according to random number table method,with 46 cases in each group.The control group was treated with Butylphthalide,and the observation group was treated with Piracetam combined with Butylphthalide double sequential therapy.The clinical efficacy,national institutes of health stroke scale(NIHSS)scores and Barthel index(BI)before and after treatment were compared between the two groups,and adverse reactions were compared between the two groups.Result:The total effective rate of observation group was higher than that of control group(P<0.05).After treatment,NIHSS score of observation group was lower than that of control group,BI was higher than that of control group,the differences were statistically significant(P<0.05).There were no significant difference in the incidences of adverse reactions between the two groups(P>0.05).Conclusion:Piracetam combined with Butylphthalein double sequential therapy in the treatment of ischemic stroke with cognitive impairment can obtain outstanding clinical efficacy,and the neurological impairment of patients has been significantly improved,and their daily living ability will also be improved,with high safety.