AR及Ki-67表达水平与三阴性乳腺癌超声特征的关系

Relationship between AR and Ki-67 Expression Levels and Ultrasonic Features of Triple-negative Breast Cancer

目的:探究雄性激素受体(AR)及Ki-67表达水平与三阴性乳腺癌超声特征的关系。方法:回顾性选取2021年5月—2023年4月在抚州市第一人民医院进行治疗的三阴性乳腺癌患者92例。所有患者均行超声检查,并采用免疫组化二步法检测Ki-67及AR的表达情况。比较Ki-67、AR阳性表达三阴性乳腺癌患者的临床参数、AR阳性表达及不同表达水平Ki-67三阴性乳腺癌患者的超声特征。结果:Ki-67及AR在三阴性乳腺癌中的阳性表达率分别为90.22%(83/92)、35.87%(33/92);Ki-67阳性患者的Ⅲ、Ⅳ期比例高于阴性患者,AR阳性患者Ⅰ、Ⅱ期比例高于阴性患者,差异均有统计学意义(P<0.05);不同Ki-67、AR表达患者的年龄、肿瘤部位、肿瘤最大直径比较,差异均无统计学意义(P>0.05);AR阳性患者边缘毛刺无成角和血流信号0、1级比例均高于阴性患者,差异均有统计学意义(P<0.05);Ki-67高表达组边缘毛刺成角、形态不规则、钙化、后方回声衰减、内部回声非低回声及血流信号2、3级比例均高于低表达组(P<0.05)。结论:AR阳性表达的三阴性乳腺癌患者,边缘毛刺无成角及血流信号0、1级的比例高,Ki-67高表达的三阴性乳腺癌患者,边缘毛刺成角、形态不规则、钙化、后方回声衰减、内部回声非低回声及血流信号2、3级比例高。

Objective:To explore the relationship between androgen receptor(AR)and Ki-67 expression levels and ultrasonic features of triple-negative breast cancer.Method:A total of 92 patients with triplenegative breast cancer who were treated in First People's Hospital of Fuzhou from May 2021 to April 2023 were retrospectively selected.All patients underwent ultrasound examination,and the expression of Ki-67 and AR were detected by immunohistochemical two-step method.The pathological features of Ki-67,AR positive expression triple-negative breast cancer patients and the ultrasound characteristics of AR positive expression and different expression levels of Ki-67 triple-negative breast cancer patients were compared.Result:The positive expression rates of Ki-67 and AR in triple-negative breast cancer were 90.22%(83/92)and 35.87%(33/92),respectively.The proportion of stageⅢandⅣin Ki-67 positive patients was higher than that in negative patients,and the proportion of stageⅠandⅡin AR positive patients was higher than that in negative patients,the differences were statistically significant(P<0.05).There were no significant differences in age,tumor site and maximum tumor diameter among patients with different Ki-67 and AR expression(P>0.05).The proportions of marginal burr without angulation and blood flow signal grade 0 and 1 in AR positive patients were higher than those in negative patients,the differences were statistically significant(P<0.05).The proportion of marginal burr angulation,irregular morphology,calcification,posterior echo attenuation,non-hypoechoic internal echo and blood flow signal grade 2 and 3 in Ki-67 high expression group were higher than those in low expression group(P<0.05).Conclusion:In triple-negative breast cancer patients with AR positive expression,the proportion of marginal burr without angulation and blood flow signal grade 0 and 1 are high.In triple-negative breast cancer patients with high Ki-67 expression,the proportion of marginal burr angulation,irregular morphology,calcification,posterior echo attenuation,non-hypoechoic internal echo and blood flow signal grade 2 and 3 are high.