甲胎蛋白阳性胃癌的临床特征及诊疗进展

Clinical Features and Progress in Diagnosis and Treatment of Alpha-fetoprotein Positive Gastric Carcinoma

甲胎蛋白(alpha-fetoprotein,AFP)多用于诊断肝癌和卵巢癌,但其在其他肿瘤中也异常表达,其中最为多见的是胃癌。这种胃癌被称为甲胎蛋白阳性胃癌(alpha-fetoprotein positive gastric carcinoma,AFPGC),诊断以血清学诊断和病理免疫组化分析为主,具有低发病率和高侵袭性、预后差的特点。本文以AFP对胃癌治疗、预后的影响,AFPGC的治疗、分子特征及不良预后的最新进展进行综述,希望能对胃癌和AFPGC的临床诊治选择提供思路。

Alpha-fetoprotein(AFP)is commonly used to diagnose liver cancer and ovarian cancer,but it is also abnormally expressed in other tumors,most commonly gastric carcinoma.This kind of gastric cancer is called alpha-fetoprotein positive gastric carcinoma(AFPGC),the diagnosis is mainly based on serological diagnosis and pathological immunohistochemical analysis,and has the characteristics of low incidence,high aggressiveness and poor prognosis.In this paper,the effects of AFP in the treatment and prognosis of gastric carcinoma,the treatment,molecular characteristics and poor prognosis of AFPGC are reviewed,hoping to provide ideas for the clinical diagnosis and treatment of gastric carcinoma and AFPGC.