幽门螺杆菌感染相关治疗的研究进展

Research Progress on the Treatment of Helicobacter Pylori Infection

幽门螺杆菌是一种革兰阴性厌氧菌,定植于人体胃窦部,是慢性胃炎、胃肠部溃疡等消化系统疾病的主要原因,也是胃癌发展最明确、最可控的危险因素。有效治疗幽门螺杆菌感染成了急需解决的问题。传统的幽门螺杆菌抗生素治疗由于抗生素耐药性增加、疗效降低及药物递送效率低下而受到限制。本综述旨在重点概述近年来幽门螺杆菌治疗进展及其用于临床治疗的挑战和前景。

Helicobacter pylori is a Gram-negative anaerobic bacterium that colonizes the human antrum,which is the main cause of digestive diseases such as chronic gastritis and gastrointestinal ulcers,and is also the most clear and controllable risk factor for the development of gastric cancer.Effective treatment of Helicobacter pylori infection has become an urgent problem.Traditional antibiotic treatment for Helicobacter pylori is limited by increased antibiotic resistance,reduced efficacy,and inefficient drug delivery.The aim of this review is to highlight the recent advances in the treatment of Helicobacter pylori and its challenges and prospects for clinical treatment.