慢性阻塞性肺疾病与高血压潜在因果关系:一项两样本孟德尔随机化研究

Potential causal relationship between chronic obstructive pulmonary disease and hypertension:a two-sample Mendelian randomization study

目的:采用两样本孟德尔随机化(MR)研究探讨慢性阻塞性肺疾病(COPD)与高血压的潜在因果关系。方法:研究数据来自全基因组关联研究汇总数据集,其中COPD汇总数据包含358369例样本(20066例COPD患者及338303例对照者),高血压研究数据包含463010例样本(54358例高血压病例和408652例对照样本)。采用逆方差加权(IVW)法为主的多种MR方法进行分析,并采用MR Egger、留一法、MR Steiger、漏斗图等方法对MR分析结果进行稳健性分析。结果:IVW随机效应模型分析结果显示,COPD与高血压的发生呈显著正相关[OR=1.005,95%CI(1.002,1.008),P=0.001]。结论:COPD与高血压存在因果关系,即COPD可能是高血压的危险因素。

Objective To explore the potential causal relationship between chronic obstructive pulmonary disease(COPD)and hypertension by using two-sample Mendelian randomization(MR)study.Methods The data were derived from the genome-wide association study pooled data set.The COPD summary data included 358369 samples(20066 COPD patients and 338303 controls),and the hypertension research data included 463010 samples(54358 hypertension cases and 408652 controls).A variety of MR methods based on inverse variance weighting(IVW)were used for analysis,and MR Egger,leave-one-out method,MR Steiger,funnel plot and other methods were used to analyze the robustness of MR analysis results.Results IVW random effect model analysis showed that COPD was significantly positively correlated with hypertension[OR=1.005,95%CI(1.002,1.008),P=0.001].Conclusions There is a causal relationship between COPD and hypertension,that is,COPD may be a risk factor for hypertension.