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氯吡格雷联合拜阿司匹林治疗急性脑梗死对其神经功能缺损评分和不良反应发生情况的影响

Effects of Clopidogrel Combined with Aspirin on Neurological Deficit Score and Adverse Reactions in Patients with Acute Cerebral Infarction
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摘要 目的:全面评估在急性脑梗死中采用氯吡格雷联合拜阿司匹林治疗对神经功能缺损评分(NIHSS)和不良反应发生情况的影响。方法:选取2022年1月—2024年1月厦门市第三医院收治的106例急性脑梗死患者作为研究对象,按照随机数表法分为对照组(n=51)和观察组(n=55)。对照组给予拜阿司匹林治疗,观察组给予氯吡格雷联合拜阿司匹林治疗,比较两组治疗前后NIHSS评分、日常生活能力量表(ADL)、血液流变学指标及不良反应发生情况。结果:治疗前,两组NIHSS、ADL得分及血液流变学比较,差异无统计学意义(P>0.05)。治疗后,观察组NIHSS低于对照组,ADL较对照组更高,差异有统计学意义(P<0.05);治疗后,观察组血细胞比容、纤维蛋白原、血沉水平均较对照组更低,差异有统计学意义(P<0.05);两组不良反应比较,差异无统计学意义(P>0.05)。结论:氯吡格雷联合拜阿司匹林用于急性脑梗死的治疗中,其效果可观,有利于改善患者的神经功能,促进血流与日常生活能力的优化,从而有效提高整体预后水平。 Objective:To evaluate the effect of clopidogrel combined with aspirin on neurological deficit score(NIHSS)and adverse reactions in acute cerebral infarction.Method:A total of 106 patients with acute cerebral infarction admitted to Xiamen Third Hospital from January 2022 to January 2024 were selected as the study objects and divided into control group(n=51)and observation group(n=55)according to random number table method.The control group was treated with aspirin,and the observation group was treated with clopidogrel combined with aspirin.NIHSS score,ADL,hemorheology indexes and the occurrence of adverse reactions were compared between the two groups before and after treatment.Result:Before treatment,there was no significant difference in NIHSS,ADL scores and hemorheology between the two groups(P>0.05).After treatment,NIHSS in observation group was lower than that in control group,ADL in observation group was higher than that in control group,and the difference was statistically significant(P<0.05).After treatment,the hematocrit,fibrinogen and ESR levels in observation group were lower than those in control group,and the difference was statistically significant(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion:The combination of clopidogrel and aspirin in acute cerebral infarction has a considerable effect,which is beneficial to improve the neurological function of patients,promote the optimization of blood flow and daily living ability,and thus effectively improve the overall prognosis.
作者 黄明月 HUANG Mingyue(Xiamen Third Hospital,Xiamen 361100,China)
机构地区 厦门市第三医院
出处 《中外医学研究》 2024年第33期69-72,共4页 CHINESE AND FOREIGN MEDICAL RESEARCH
关键词 氯吡格雷 拜阿司匹林 急性脑梗死 神经功能缺损评分 不良反应 Clopidogrel Worship aspirin Acute cerebral infarction Neurological function defect score Adverse effect
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