玉屏风汤联合布地奈德鼻腔冲洗治疗过敏性鼻炎(肺脾气虚证)患者的效果及对炎症因子、免疫功能的影响

Effect of Yupingfeng Decoction Combined with Budesonide Nasal Irrigation on Patients with Allergic Rhinitis(Syndrome of Qi Deficiency of Lung and Spleen)and Its Influence on Inflammatory Factors and Immune Function

目的:探讨玉屏风汤联合布地奈德鼻腔冲洗治疗过敏性鼻炎(肺脾气虚证)患者的效果及对炎症因子、免疫功能的影响。方法:选取2023年1—12月广东省妇幼保健院收治的86例过敏性鼻炎(肺脾气虚证)患者,按照随机数字表法分两组,各43例。对照组给予布地奈德鼻腔冲洗治疗,观察组在对照组基础上加用玉屏风汤治疗,两组均治疗2周。比较两组临床疗效、中医症状积分、炎症因子及免疫功能因子水平。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组中医症状积分、白细胞介素-4(IL-4)、白细胞介素-6(IL-6)均低于对照组,γ干扰素(IFN-γ)高于对照组,差异均有统计学意义(P<0.05)。治疗后,观察组免疫球蛋白M(IgM)、免疫球蛋白G(IgG)与免疫球蛋白A(IgA)均高于对照组,差异均有统计学意义(P<0.05)。结论:玉屏风汤联合布地奈德鼻腔冲洗可提升过敏性鼻炎(肺脾气虚证)患者的治疗效果,减轻患者局部炎症反应,提升其免疫功能。

Objective:To investigate the effect of Yupingfeng Decoction combined with Budesonide nasal irrigation on allergic rhinitis(syndrome of Qi deficiency of lung and spleen)and its influence on inflammatory factors and immune function.Method:A total of 86 patients with allergic rhinitis(syndrome of Qi deficiency of lung and spleen)admitted to Guangdong Maternal and Child Health Hospital from January to December 2023 were selected and divided into two groups according to random number table method,with 43 cases in each group.The control group was given Budesonide nasal irrigation treatment,and the observation group was treated with Yupingfeng Decoction on the basis of the control group.Both groups were treated for 2 weeks.The clinical efficacy,traditional Chinese medicine symptom score,inflammatory factors and immune function factors were compared between the two groups.Result:The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).After treatment,traditional Chinese medicine symptom score,interleukin-4(IL-4)and interleukin-6(IL-6)in observation group were lower than those in control group,and interferonγ(IFN-γ)was higher than that in control group,the differences were statistically significant(P<0.05).After treatment,immunoglobulin M(IgM),immunoglobulin G(IgG)and immunoglobulin A(IgA)in observation group were higher than those in control group,the differences were statistically significant(P<0.05).Conclusion:Yupingfeng Decoction combined with Budesonide nasal irrigation can improve the therapeutic effect of allergic rhinitis(syndrome of Qi deficiency of lung and spleen),reduce the local inflammatory response of patients,and enhance their immune function.