干眼熏蒸联合环孢素滴眼液(Ⅱ)及玻璃酸钠滴眼液治疗混合型干眼症的效果

Effect of Dry Eye Fumigation and Steaming Combined with Ciclosporin Eye Drops(Ⅱ)and Sodium Hyaluronate Eye Drops in the Treatment of Mixed Xerophthalmia

目的:观察干眼熏蒸联合环孢素滴眼液(Ⅱ)及玻璃酸钠滴眼液治疗混合型干眼症的效果。方法:选取2021年9月—2023年12月南昌爱尔眼科医院收治的干眼症患者100例,采用随机数字表法将患者分为常规组和联合组,每组50例。常规组采用干眼熏蒸联合玻璃酸钠滴眼液治疗,联合组采用干眼熏蒸联合环孢素滴眼液(Ⅱ)及玻璃酸钠滴眼液治疗,均治疗1个月。比较两组治疗效果、泪膜破裂时间(breakup time of tear film,BUT)、角膜荧光素染色(fluorescent staining,FL)、泪河高度(tear meniscus height,TMH)、泪液分泌试验(SchirmerⅠtest,SⅠt)、干眼症状评分、不良反应发生率。结果:联合组治疗总有效率高于常规组(P<0.05)。与治疗前比较,治疗1个月后两组BUT均延长,角膜FL评分均降低,联合组BUT长于常规组,角膜FL评分低于常规组(P<0.05)。与治疗前比较,治疗1个月后两组TMH均升高,SⅠt均延长,联合组TMH高于常规组,SⅠt长于常规组(P<0.05)。与治疗前比较,治疗2周、1个月后两组干眼症状评分均降低,联合组干眼症状评分均低于常规组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:干眼熏蒸联合环孢素滴眼液(Ⅱ)及玻璃酸钠滴眼液治疗混合型干眼症,能够提高治疗总有效率,改善干眼症状,提高泪膜稳定性。

Objective:To observe the effect of dry eye fumigation and steaming combined with Ciclosporin Eye Drops(Ⅱ)and Sodium Hyaluronate Eye Drops in the treatment of mixed xerophthalmia.Method:A total of 100 patients with xerophthalmia treated in Nanchang Aier Eye Hospital from September 2021 to December 2023 were selected and divided into conventional group and combined group by random number table method,with 50 cases in each group.The conventional group was treated with dry eye fumigation and steaming combined with Sodium Hyaluronate Eye Drops,and the combined group was treated with dry eye fumigation and steaming combined with Ciclosporin Eye Drops(Ⅱ)and Sodium Hyaluronate Eye Drops,all patients were treated for 1 month.The treatment effect,breakup time of tear film(BUT),corneal fluorescent staining(FL),tear meniscus height(TMH),SchirmerⅠtest(SⅠt),dry eye symptom score,incidence of adverse reactions were compared between the two groups.Result:The total effective rate of combined group was higher than that of conventional group(P<0.05).Compared with before treatment,BUT were prolonged and corneal FL scores were decreased in both groups after 1 month of treatment,BUT in combined group was longer than that in conventional group,corneal FL score was lower than that in conventional group(P<0.05).Compared with before treatment,TMH were increased and SⅠt were prolonged in both groups after 1 month of treatment,TMH in combined group was higher than that in conventional group,SⅠt was longer than that in conventional group(P<0.05).After 2 weeks and 1 month of treatment,the dry eye symptom scores of both groups were decreased,and the dry eye symptom scores of combined group were lower than those of conventional group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Dry eye fumigation and steaming combined with Ciclosporin Eye Drops(Ⅱ)and Sodium Hyaluronate Eye Drops in the treatment of mixed xerophthalmia can improve the total effective rate,improve the symptoms of dry eye and improve the stability of tear film.