复方丹参滴丸联合酒石酸美托洛尔治疗冠心病心绞痛的近期预后及对患者氧化应激指标的影响

Effect of Compound Danshen Dropping Pills Combined with Metoprolol Tartrate on the Short-term Prognosis and Oxidative Stress Indexes of Patients with Coronary Heart Disease and Angina Pectoris

目的:分析复方丹参滴丸联合酒石酸美托洛尔治疗冠状动脉粥样硬化性心脏病(CHD)心绞痛患者的近期预后及对氧化应激指标的影响。方法:选择2022年8月—2023年8月辽宁省金秋医院综合老年医学科一病房收治80例CHD心绞痛患者样本,通过随机数字表法分为试验组(n=40)、对照组(n=40)。对照组给予CHD心绞痛基础治疗联合酒石酸美托洛尔,试验组在对照组基础上联合复方丹参滴丸治疗,两组治疗时间均为3个月。比较两组临床总有效率、心绞痛发作频率、心绞痛发作持续时间、硝酸甘油用量、心功能指标、血流动力学指标、氧化应激指标及心血管不良事件发生率。结果:试验组临床总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,试验组心绞痛发作频率低于对照组,心绞痛发作持续时间短于对照组,硝酸甘油用量少于对照组,差异均有统计学意义(P<0.05)。治疗后,试验组左室射血分数(LVEF)高于对照组,左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)水平均低于对照组,差异均有统计学意义(P<0.05)。治疗后,试验组纤维蛋白原(FIB)、血沉(ESR)、全血低切黏度(NBL)、全血高切黏度(NBH)均低于对照组,差异均有统计学意义(P<0.05)。治疗后,试验组总超氧化物歧化酶(T-SOD)、谷胱甘肽过氧化物酶(GSH-Px)水平均高于对照组,丙二醛(MDA)、乳酸脱氢酶(LD)水平均低于对照组,差异均有统计学意义(P<0.05)。随访3个月,两组均未发生心血管不良事件。结论:CHD心绞痛患者采用复方丹参滴丸联合酒石酸美托洛尔治疗效果显著,可降低心绞痛发作频率及发作持续时间,减少硝酸甘油用量,改善心功能血流动力学指标,调控氧化应激反应,心血管不良事件发生率较低,安全性好。

Objective:To analyze the short-term prognosis of Compound Danshen Dropping Pills combined with Metoprolol Tartrate in the treatment of angina pectoris in patients with coronary atherosclerotic heart disease(CHD)and its effects on oxidative stress indexes.Method:A total of 80 CHD patients with angina pectoris were selected from the First Ward of Comprehensive Geriatric Department of Liaoning Province Jinqiu Hospital from August 2022 to August 2023,and they were divided into experimental group(n=40)and control group(n=40)by random number table method.The control group was given basic treatment of CHD angina pectoris combined with Metoprolol Tartrate,and the experimental group was given combined treatment with Compound Danshen Dropping Pills on the basis of the control group.The treatment time of both groups was 3 months.The clinical total effective rate,frequency of angina pectoris attack,duration of angina pectoris attack,dosage of nitroglycerin,cardiac function index,hemodynamic index,oxidative stress index and incidence of cardiovascular adverse events were compared between the two groups.Result:The clinical total effective rate of experimental group was higher than that of control group,the difference was statistically significant(P<0.05).After treatment,the frequency of angina pectoris attack in experimental group was lower than that in control group,the duration of angina pectoris attack was shorter than that in control group,and the dosage of Nitroglycerin was less than that in control group,with statistical significance(P<0.05).After treatment,left ventricular ejection fraction(LVEF)in experimental group was higher than that Medical Innovation of China Vol.21,No.33 November,2024 in control group,and left ventricular end-systolic diameter(LVESD)and left ventricular end-diastolic diameter(LVEDD)levels were lower than those in control group,with statistical significance(P<0.05).After treatment,fibrinogen(FIB),erythrocyte sedimentation rate(ESR),whole blood viscosity low cut(NBL)and whole blood viscosity high cut(NBH)in experimental group were lower than those in control group,the differences were statistically significant(P<0.05).After treatment,the levels of total superoxide dismutase(T-SOD)and glutathione peroxidase(GSH-Px)in experimental groups were higher than those in control group,while the levels of malondialdehyde(MDA)and lactate dehydrogenase(LD)in experimental group were lower than those in control group,with statistical significance(P<0.05).After 3 months follow-up,no adverse cardiovascular events occurred in either group.Conclusion:In CHD patients with angina pectoris,the treatment of Compound Danshen Dropping Pills combined with Metoprolol Tartrate has significant effects,which can reduce the frequency and duration of angina pectoris attack,reduce the dosage of Nitroglycerin,improve cardiac function hemodynamic indexes,regulate oxidative stress response,and reduce the incidence of cardiovascular adverse events with good safety.