富马酸依美斯汀滴眼液联合普拉洛芬滴眼液在过敏性结膜炎患者中的应用效果

Application Effect of Emedastine Difumarate Eye Drops Combined with Pranoprofen Eye Drops in Patients with Allergic Conjunctivitis

目的:探讨富马酸依美斯汀滴眼液联合普拉洛芬滴眼液在过敏性结膜炎患者中的应用效果。方法:选取2021年3月—2024年3月厦门市湖里区妇幼保健院收治的96例过敏性结膜炎患者作为研究对象,按照治疗方式分为观察组和对照组,各48例。对照组给予富马酸依美斯汀滴眼液治疗,观察组给予富马酸依美斯汀滴眼液联合普拉洛芬滴眼液治疗。比较两组泪膜稳定性、泪液蛋白水平及不良反应发生情况。结果:治疗后,两组泪膜破裂时间(BUT)、泪液分泌量(SⅠT)、角膜荧光素染色(FL)评分均低于治疗前,且观察组均低于对照组,差异均有统计学意义(P<0.05)。治疗后,两组泪液乳铁蛋白(LF)、总蛋白(TP)、分泌型免疫球蛋白A(sIgA)均高于治疗前,且观察组均高于对照组,差异均有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:富马酸依美斯汀滴眼液联合普拉洛芬滴眼液能够明显改善过敏性结膜炎患者泪膜稳定性及泪液蛋白水平。

Objective:To investigate the effect of Emedastine Difumarate Eye Drops combined with Pranoprofen Eye Drops in patients with allergic conjunctivitis.Method:A total of 96 patients with allergic conjunctivitis admitted to Huli District Maternal and Child Health Hospital of Xiamen from March 2021 to March 2024 were selected as the study objects,and they were divided into observation group and control group according to treatment methods,with 48 cases in each group.The control group was treated with Emedastine Difumarate Eye Drops,and the observation group was treated with Emedastine Difumarate Eye Drops combined with Pranoprofen Eye Drops.The stability of tear film,the level of tear protein and the occurrence of adverse reactions were compared between the two groups.Result:After treatment,break-up time(BUT),Schirmer test(SⅠT)and corneal fluorescein staining(FL)scores in two groups were lower than those before treatment,and those in observation group were lower than those in control group,the differences were statistically significant(P<0.05).After treatment,lacrimal lactoferrin(LF),total protein(TP)and secreted immunoglobulin A(sIgA)in two groups were higher than those before treatment,and those in observation group were higher than those in control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Emedastine Difumarate Eye Drops combined with Pranoprofen Eye Drops can significantly improve the stability of tear film and the level of tear protein in patients with allergic conjunctivitis.