以早期肺功能监测为指导的干预在反复下呼吸道感染患儿中的应用

Application of Intervention Guided by Early Pulmonary Function Monitoring in Children with Recurrent Lower Respiratory Tract Infections

目的:探究以早期肺功能监测为指导的干预对反复下呼吸道感染患儿的影响。方法:选择2022年9月—2023年12月晋江市医院收治的80例反复下呼吸道感染患儿,根据随机数字表法分为两组,各40例。对照组进行常规下呼吸道感染干预治疗,观察组则以早期肺功能监测为指导进行针对性干预。比较两组疾病控制总有效率、干预前后肺功能指标[呼气峰值流速(PEF)、第1秒用力呼气容积占预计值的百分比(FEV_(1)%pred)及?第1秒用力呼气容积占用力肺活量的比值(FEV_(1)/FVC)]及免疫状态指标[免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)、补体C3、CD8^(+)、CD19^(+)、CD3^(+)及CD4^(+)]。结果:观察组疾病控制总有效率显著高于对照组,差异有统计学意义(P<0.05)。干预前,两组肺功能指标及免疫状态指标比较,差异均无统计学意义(P>0.05);干预后,观察组PEF、FEV_(1)%pred、FEV_(1)/FVC均显著高于对照组,CD8^(+)、CD19^(+)均显著低于对照组,IgA、IgG、IgM、补体C3、CD3^(+)、CD4^(+)均显著高于对照组,差异均有统计学意义(P<0.05)。结论:以早期肺功能监测为指导的干预有助于反复下呼吸道感染患儿的疾病控制,调控其免疫状态,有助于患儿肺功能状态的改善。

Objective:To explore the effects of intervention guided by early pulmonary function monitoring on children with recurrent lower respiratory tract infection.Method:A total of 80 children with recurrent lower respiratory tract infection treated in Jinjiang Municipal Hospital from September 2022 to December 2023 were selected,they were divided into two groups according to random number table method,with 40 cases in each group.The control group received routine intervention treatment for lower respiratory tract infection,and the observation group received targeted intervention guided by early pulmonary function monitoring.The total effective rate of disease control,pulmonary function indexes[peak expiratory flow rate(PEF),percentage of forced expiratory volume in the first second to the expected value(FEV_(1)%pred),ratio of forced expiratory volume in the first second to forced vital capacity(FEV_(1)/FVC)]and immune status indexes[immunoglobulin A(IgA)and immunoglobulin G(IgG),immunoglobulin M(IgM),complement C3,CD8^(+),CD19^(+),CD3^(+)and CD4^(+)]were compared between the two groups.Result:The total effective rate of disease control in observation group was significantly higher than that in control group,the difference was statistically significant(P<0.05).Before intervention,there were no significant differences in pulmonary function indexes and immune status indexes between the two groups(P>0.05).After intervention,PEF,FEV_(1)%pred and FEV_(1)/FVC in observation group were significantly higher than those in control group,CD8^(+)and CD19^(+)were significantly lower than those in control group,IgA,IgG,IgM,complement C3,CD3^(+)and CD4^(+)were significantly higher than those in control group,the differences were statistically significant(P<0.05).Conclusion:Intervention guided by early pulmonary function monitoring is helpful for disease control,regulation of immune status and improvement of pulmonary function in children with recurrent lower respiratory tract infection.