低强度脉冲超声波与低能量冲击波治疗血管性勃起功能障碍的临床效果

Clinical Effect of Low Intensity Pulsed Ultrasonic Wave and Low Energy Shock Wave in the Treatment of Vascular Erectile Dysfunction

目的:探讨血管性勃起功能障碍患者采用低强度脉冲超声波与低能量冲击波治疗的临床效果。方法:本研究将2022年10月—2023年10月南华大学附属南华医院收治的血管性勃起功能障碍患者118例作为研究对象,随机分为观察组(n=59)、对照组(n=59)。观察组采用低强度脉冲超声波治疗,对照组采用低能量冲击波治疗。比较两组动脉性、静脉性勃起功能障碍的超声参数、血清因子水平、临床疗效及性生活满意情况。结果:治疗前,两组动脉性勃起功能障碍阴茎彩色多普勒超声参数比较,差异均无统计学意义(P>0.05);治疗后,两组收缩期峰值流速(PSV)均增加,舒张末期流速(EDV)均下降,观察组PSV较对照组高,差异均有统计学意义(P<0.05)。治疗前,两组静脉性勃起功能障碍阴茎彩色多普勒超声参数比较,差异均无统计学意义(P>0.05);治疗后,两组PSV、阻力指数(RI)均增加,EDV均下降,观察组PSV、RI均较对照组高,EDV较对照组低,差异均有统计学意义(P<0.05)。治疗后3 d,观察组?血管内皮生长因子(VEGF)、血管生成素Ⅰ(ANGⅠ)水平均较对照组高,差异均有统计学意义(P<0.05)。治疗后3 d,两组血管生成素Ⅱ(ANGⅡ)较治疗前均显著降低,且观察组低于对照组,差异均有统计学意义(P<0.05)。治疗后3 d,两组脑源性神经营养因子(BDNF)比较,差异无统计学意义(P>0.05)。观察组治疗总有效率(96.61%)较对照组(84.75%)高(P<0.05);观察组性生活满意度(94.92%)较对照组(81.36%)高(P<0.05)。结论:与低能量冲击波治疗相比,低强度脉冲超声波治疗血管性勃起功能障碍能促进患者动静脉血流量的平衡和恢复,促进血管的再生,从而提高治疗效果及性生活满意度。

Objective:To investigate the clinical effect of low intensity pulsed ultrasonic wave and low energy shock wave in the treatment of patients with vascular erectile dysfunction.Method:In this study,118 patients with vascular erectile dysfunction admitted to Affiliated Nanhua Hospital,University of South China from October 2022 to October 2023 were selected as research objects and randomly divided into observation group(n=59)and control group(n=59).The observation group was treated with low intensity pulsed ultrasonic wave,and the control group was treated with low energy shock wave.The ultrasound parameters of arterial and venous erectile dysfunction,serum factors levels,clinical efficacy and sexual life satisfaction were compared between two groups.Result:Before treatment,there were no significant differences in color Doppler ultrasonography parameters of arterial erectile dysfunction between the two groups(P>0.05).After treatment,the peak systolic velocity(PSV)increased and the end diastolic velocity(EDV)decreased in both groups,PSV in observation group was higher than that in control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in color Doppler ultrasonography parameters of venous erectile dysfunction between the two groups(P>0.05).After treatment,the PSV and resistance index(RI)increased and the EDV decreased in both groups,PSV and RI in observation group were higher than those in control group,EDV was lower than that in control group,the differences were statistically significant(P<0.05).3 days after treatment,vascular endothelial growth factor(VEGF)and angiopoietinⅠ(ANGⅠ)levels in observation group were higher than those in control Medical Innovation of China Vol.21,No.33 November,2024 group,the differences were statistically significant(P<0.05).3 days after treatment,angiopoietinⅡ(ANGⅡ)in both groups were significantly lower than those before treatment,and that in the observation group was lower than that the control group,the differences were statistically significant(P<0.05).3 days after treatment,there was no significant difference in brain-derived neurotrophic factor(BDNF)between the two groups(P>0.05).The total effective rate of observation group(96.61%)was higher than that of control group(84.75%)(P<0.05).The sexual life satisfaction of observation group(94.92%)was higher than that of control group(81.36%)(P<0.05).Conclusion:Compared with low energy shock wave therapy,low intensity pulsed ultrasonic wave therapy for vascular erectile dysfunction can promote the balance and recovery of patients'arteriovenous blood flow,promote the regeneration of blood vessels,and improve the therapeutic effect and sexual life satisfaction.