Vitapex糊剂和盐酸米诺环素在根尖周炎伴牙周炎中的应用

Application of Vitapex Paste and Minocycline Hydrochloride in Treating Apical Periodontitis with Periodontitis

目的:评估Vitapex糊剂与盐酸米诺环素软膏联合应用对根尖周炎及牙周炎治疗成效的影响。方法:本研究于2022年1月—2023年12月进行,共纳入大兴安岭地区人民医院102例根尖周炎伴牙周炎患者。通过摸球法分组,奇数为对照组(n=51),偶数为试验组(n=51)。两组患者均进行了根管治疗,对照组使用碘酚和棉签填充,牙周袋注射碘甘油;试验组填充Vitapex糊剂,并在牙周袋中使用盐酸米诺环素软膏。两组总疗程持续4周。对比两组细菌清除率(球状菌、梭状杆菌、线状菌、杆菌、螺旋菌)、牙周状况[牙周袋深度(periodontal pocket depth,PD)、出血指数(bleeding index,BI)、菌斑指数(plaque index,PLI)、牙龈指数(gingival index,GI)]、炎症细胞因子[白细胞介素-6(interleukin-6,IL-6)、白细胞介素-17(interleukin-17,IL-17)、白细胞介素-1β(interleukin-1β,IL-1β)、C反应蛋白(C reactive protein,CRP)]、口腔健康影响程度[口腔健康影响程度量表(oral health impact profile-14,OHIP-14)评分]。结果:试验组球状菌、梭状杆菌、线状菌、杆菌、螺旋菌的细菌清除率均高于对照组,差异均有统计学意义(P<0.05);治疗后,试验组PD、BI、PLI、GI和IL-6、IL-17、IL-1β、CRP水平均低于对照组,差异均有统计学意义(P<0.05);治疗后,试验组OHIP-14各项评分均低于对照组,差异均有统计学意义(P<0.05)。结论:Vitapex糊剂与盐酸米诺环素在治疗根尖周炎及牙周炎时,能有效提升细菌的清除效果并改进牙周健康状况,降低炎症细胞因子水平,提升口腔健康程度,是一种高效的治疗方案。

Objective:To evaluate the efficacy of the combined application of Vitapex paste and Minocycline Hydrochloride Ointment in the treatment of periapical periodontitis and periodontitis.Method:This study was conducted from January 2022 to December 2023,including 102 patients with periapical periodontitis and periodontitis at the People's Hospital of the Daxing'anling Region.Patients were assigned to groups using a draw-ball method,with odd numbers in the control group(n=51)and even numbers in the experimental group(n=51).Both groups received root canal treatment.The control group was treated with iodophenol and a cotton swab filling,and iodine glycerin injections into the periodontal pockets.The experimental group was treated with Vitapex paste filling and Minocycline Hydrochloride Ointment in the periodontal pockets.The total treatment lasted 4 weeks in both groups.The bacterial clearance rates(globular bacteria,clostridium bacteria,linear bacteria,Bacillus and spirulina),periodontal conditions[periodontal pocket depth(PD),bleeding index(BI),plaque index(PLI),gingival index(GI)],inflammatory cytokines[interleukin-6(IL-6),interleukin-17(IL-17),interleukin-1β(IL-1β),C reactive protein(CRP)],and oral health impact[oral health impact profile-14(OHIP-14)score]were compared between the two groups.Result:The bacterial clearance rates of globular bacteria,clostridium bacteria,linear bacteria,Bacillus and spirulina in experimental group were higher than those in control group,with statistical significance(P<0.05).After treatment,the levels of PD,BI,PLI,GI,IL-6,IL-17,IL-1βand CRP in experimental groups were lower than those in control group,the differences were statistically significant(P<0.05).After treatment,all the scores of OHIP-14 in experimental group were lower than those in control group,the differences were statistically significant(P<0.05).Conclusion:The combination of Vitapex paste and Minocycline Hydrochloride in the treatment of periapical periodontitis and periodontitis effectively enhances bacterial clearance and improves periodontal health conditions,reduces levels of inflammatory cytokines,and improves oral health,proving to be an efficient treatment regimen.