卡前列素氨丁三醇在宫缩乏力性产后出血患者中的应用效果及对宫缩情况、血液指标的影响

Application Effect of Carboprost Tromethamine on Uterine Inertia Postpartum Haemorrhage and Its Influence on Uterine Contraction and Blood Indexes

目的:探究卡前列素氨丁三醇在宫缩乏力性产后出血患者中的应用效果及对宫缩情况、血液指标的影响。方法:将2020年5月—2023年5月麻城市妇幼保健院收治的80例宫缩乏力性产后出血患者根据随机数字表法分为对照组(n=40)和观察组(n=40)。对照组采用米索前列醇进行治疗,观察组则在对照组的基础上加用卡前列素氨丁三醇治疗。比较两组治疗总有效率、不良反应发生率、子宫复旧情况(子宫底高度及子宫体积)、宫缩指标(宫缩强度、宫缩张力及宫缩幅度)及血液指标[一氧化氮(NO)及一氧化氮合酶(NOS)]。结果:观察组治疗总有效率显著高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05);产后1、3、5 d,观察组子宫底高度均显著低于对照组,差异均有统计学意义(P<0.05);产后1、2、4、6周,观察组的子宫体积均显著小于对照组,差异均有统计学意义(P<0.05);治疗前两组宫缩指标及血液指标比较,差异均无统计学意义(P>0.05);治疗后观察组宫缩指标均显著高于对照组,血液指标均显著低于对照组,差异均有统计学意义(P<0.05)。结论:卡前列素氨丁三醇在宫缩乏力性产后出血患者中的应用效果较好,可促进宫缩及子宫复旧,下调NO、NOS水平。

Objective:To investigate the application effect of Carboprost Tromethamine on uterine inertia postpartum haemorrhage and its influence on uterine contraction and blood indexes.Method:A total of 80 patients with uterine inertia postpartum haemorrhage admitted to Macheng Maternal and Child Health Hospital from May 2020 to May 2023 were divided into control group(n=40)and observation group(n=40)according to random number table method.The control group was treated with Misoprostol,and the observation group was treated with Carboprost Tromethamine on the basis of the control group.The total effective rate,incidence of adverse reactions,uterine involution(uterine floor height and uterine volume),uterine contraction indexes(uterine contraction strength,uterine contraction tension and uterine contraction amplitude)and blood indexes[nitric oxide(NO)and nitric oxide synthase(NOS)]were compared between the two groups.Result:The total effective rate of the observation group was significantly higher than that of the control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).1,3,5 days after delivery,the uterine floor height in observation group were significantly lower than those in control group,the differences were statistically significant(P<0.05).1,2,4 and 6 weeks after delivery,the uterine volume of observation group were significantly lower than those of control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in uterine contraction indexes and blood indexes between the two groups(P>0.05).After treatment,the uterine contraction indexes of observation group were significantly higher than those of control group,and the blood index were significantly lower than those of control group,the differences were statistically significant(P<0.05).Conclusion:The application effect of Carboprost Medical Innovation of China Vol.21,No.33 November,2024 Tromethamine in patients with uterine inertia postpartum haemorrhage is better,it can promote uterine contraction and uterine involution,and reduce the levels of NO and NOS.