阿立哌唑联合喹硫平治疗女性精神分裂症的效果及对生殖激素、糖脂代谢的影响

Effect of Aripiprazole Combined with Quetiapine in the Treatment of Female Schizophrenia and the Impact on Reproductive Hormones,Glucose and Lipid Metabolism

目的:探讨阿立哌唑联合喹硫平治疗女性精神分裂症的效果及对生殖激素、糖脂代谢的影响。方法:回顾性收集2021年6月—2023年6月宜春市第三人民医院收治的60例女性精神分裂症患者的临床资料,根据治疗方式的不同分为对照组(n=29)和观察组(n=31)。对照组给予喹硫平治疗,观察组给予阿立哌唑联合喹硫平治疗。比较两组临床疗效、治疗前后生殖激素[催乳素(PRL)、雌二醇(E2)]、糖脂代谢指标[总胆固醇(TC)、空腹血糖(FPG)、餐后2 h血糖(2 h PG)、甘油三酯(TG)]及不良反应发生情况。结果:治疗后,对照组总有效率为65.52%,明显低于观察组的90.32%(P<0.05)。治疗后,对照组PRL、TC、FPG、2 h PG、TG均高于治疗前,E2低于治疗前,而观察组PRL、TC、FPG、2 h PG、TG均低于对照组,E2高于对照组,差异均有统计学意义(P<0.05);但观察组PRL、E2、TC、FPG、2 h PG、TG与治疗前比较,差异均无统计学意义(P>0.05)。两组不良反应发生率比较,差异无统计学意义(χ^(2)=0.773,P=0.379)。结论:阿立哌唑联合喹硫平治疗女性精神分裂症可明显提升临床效果,降低药物对患者生殖激素、糖脂代谢的影响,且用药安全性好。

Objective:To investigate the effect of Aripiprazole combined with Quetiapine in the treatment of female schizophrenia and its effects on reproductive hormone,glucose and lipid metabolism.Method:Clinical data of 60 female schizophrenia patients admitted to the Third People's Hospital of Yichun City from June 2021 to June 2023 were retrospectively collected and divided into control group(n=29)and observation group(n=31)according to different treatment methods.The control group was treated with Quetiapine,and the observation group was treated with Aripiprazole combined with Quetiapine.The clinical efficacy,reproductive hormones[prolactin(PRL),estradiol(E2)],glucose and lipid metabolism indexes[total cholesterol(TC),fasting plasma glucose(FPG),2 h postmeal plasma glucose(2 h PG),triglyceride(TG)]before and after treatment,and the occurrence of adverse reactions were compared.Result:After treatment,the total effective rate of control group was 65.52%,which was significantly lower than 90.32%of observation group(P<0.05).After treatment,PRL,TC,FPG,2 h PG and TG of control group were higher than those before treatment,E2 was lower than that before treatment,while PRL,TC,FPG,2 h PG and TG of observation group were lower than those in control group,E2 was higher than that in control group,the differences were statistically significant(P<0.05).However,there were no significant differences in PRL,E2,TC,FPG,2 h PG and TG in observation group compared with those before treatment(P>0.05).There was no significant difference in the adverse reaction rate between the two groups(χ^(2)=0.773,P=0.379).Conclusion:Aripiprazole combined with Quetiapine in the treatment of female schizophrenia can significantly improve the clinical efficacy,reduce the effects of drugs on reproductive hormones,glucose and lipid metabolism of patients,and the drug safety is good.