宁泌泰联合盐酸坦索罗辛治疗良性前列腺增生的效果及对血清IL-6、NLR水平的影响

Effect of Ningmitai Combined with Tamsulosin Hydrochloride in the Treatment of Benign Prostatic Hyperplasia and Its Influence on Serum IL-6 and NLR Levels

目的:研究宁泌泰联合盐酸坦索罗辛治疗良性前列腺增生(BPH)的效果及对血清白细胞介素-6(IL-6)、中性粒细胞-淋巴细胞比值(NLR)水平的影响。方法:选取2020年8月—2023年8月在上饶市立医院治疗的88例BPH患者作为研究对象,随机分为两组,各44例。单一组口服盐酸坦索罗辛,联合组在单一组基础上加用宁泌泰口服治疗。比较两组临床疗效、并发症发生率,统计两组治疗前后的前列腺症状[国际前列腺症状评分表(IPSS)]、生活质量[生活质量指数评分表(QOL)]、尿动力学指标[峰值尿流率(Qmax)、残余尿量(RU)、前列腺体积(PV)]、前列腺特异性抗原(PSA)、性激素指标[睾酮、雌二醇(E_(2))]及炎症指标[血清IL-6、前列腺液白细胞计数(WBC)、NLR]。结果:联合组治疗总有效率高于单一组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。治疗后,两组IPSS评分、QOL评分、RU、PV、血清IL-6、PSA、外周血NLR和前列腺液WBC水平均低于治疗前,Qmax、E_(2)水平均高于治疗前,差异均有统计学意义(P<0.05),且联合组IPSS评分、QOL评分、RU、PV、血清IL-6、PSA、外周血NLR和前列腺液WBC水平均低于单一组,Qmax、E_(2)水平均高于单一组,差异均有统计学意义(P<0.05)。结论:宁泌泰与盐酸坦索罗辛联合治疗BPH效果突出,且在缓解临床症状、炎症反应和改善尿动力学、激素分泌、生活质量方面能获得理想效果,临床应用价值较高。

Objective:To study the effect of Ningmitai combined with Tamsulosin Hydrochloride on benign prostatic hyperplasia(BPH)and the level of serum interleukin-6(IL-6)and neutrophil-lymphocyte ratio(NLR).Method:A total of 88 BPH patients treated in Shangrao Municipal Hospital from August 2020 to August 2023 were selected as the study objects and randomly divided into two groups,with 44 cases in each group.The single group was given Tamsulosin Hydrochloride orally,and the combination group was given Ningmitai orally on the basis of the single group.The clinical efficacy and complication rate of the two groups were compared.Prostate symptoms[international prostate symptoms scale(IPSS)],quality of life[QOL],urodynamic indexes[peak urine flow rate(Qmax),residual urine volume(RU),prostate volume(PV)],prostate-specific antigen(PSA),sex hormone indexes[testosterone,ediol(E_(2))]and inflammatory markers[serum IL-6,prostatic fluid white blood cell count(WBC),NLR]in the two groups before and after treatment were analyzed.Result:The total effective rate of combination group was higher than that of single group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of total adverse reactions between the two groups(P>0.05).After treatment,IPSS scores,QOL scores,RU,PV,serum IL-6,PSA,peripheral blood NLR and prostatic fluid WBC levels in two groups were lower than those before treatment,and Qmax and E_(2) levels were higher than those before treatment,the differences were statistically significant(P<0.05).Moreover,IPSS score,QOL score,RU,PV,serum IL-6,PSA,peripheral blood NLR and prostatic fluid WBC levels in combination group were lower than those in single group,while Qmax and E_(2) levels were higher than those in single group,the differences were statistically significant(P<0.05).Conclusion:Ningmitai combined with Tamsulosin Hydrochloride in the treatment of BPH has outstanding efficacy,and can achieve ideal effects in relieving clinical symptoms,inflammatory response,improving urodynamics,hormone secretion and quality of life,and has high clinical application value.