丙酸倍氯米松气雾剂联合酮替芬治疗咳嗽变异性哮喘患儿的临床研究

Clinical Study of Beclomethasone Dipropionate Aerosol Combined with Ketotifen in the Treatment of Children with Cough Variant Asthma

目的:探讨丙酸倍氯米松气雾剂联合酮替芬治疗咳嗽变异性哮喘患儿的临床效果。方法:选取2021年3月—2022年3月寿光市人民医院小儿一科收治的84例咳嗽变异性哮喘患儿为研究对象,按随机数字表法分为对照组(n=42)和研究组(n=42)。两组均予以基础对症治疗,对照组予以丙酸倍氯米松气雾剂治疗,观察组予以丙酸倍氯米松气雾剂联合酮替芬治疗。对比两组干预前后炎症因子[血清白介素-4(IL-4)、白介素-5(IL-5)、白介素-8(IL-8)及白介素-13(IL-13)]水平、肺功能[第1秒用力呼气容积(FEV1)、FEV1/用力肺活量(FEV1/FVC)、呼气流量峰值(PEF)]、咳嗽消失时间、咯痰消失时间及住院时间。结果:干预后,两组IL-4、IL-5、IL-8、IL-13水平均降低,且研究组均低于对照组(P<0.05);干预后,两组FEV1、FEV1/FVC、PEF均升高,且研究组均较对照组高(P<0.05);研究组咳嗽、咯痰消失时间均早于对照组,住院时间较对照组短(P<0.05)。结论:丙酸倍氯米松气雾剂联合酮替芬应用于咳嗽变异性哮喘患儿,可改善患儿的炎症反应及肺功能,减轻临床症状,缩短住院时间。

Objective:To explore the clinical effect of Beclometasone Dipropionate Inhalation Aerosol combined with Ketotifen in the treatment of children with cough variant asthma.Method:A total of 84 children with cough variant asthma admitted to Department of PediatricⅠ,Shouguang People's Hospital from March 2021 to March 2022 were selected as the study objects,and they were divided into control group(n=42)and study group(n=42)according to random number table method.Both groups were given basic symptomatic treatment,the control group was treated with Beclometasone Dipropionate Inhalation Aerosol,the observation group was treated with Beclometasone Dipropionate Inhalation Aerosol combined with Ketotifen.The levels of inflammatory factors[serum interleukin-4(IL-4),interleukin-5(IL-5),interleukin-8(IL-8)and interleukin-13(IL-13)],pulmonary function[forced expiratory volume in one second(FEV1),FEV1/forced vital capacity(FEV1/FVC),peak expiratory flow(PEF)]before and after intervention and disappearance time of cough and sputum and hospital stay were compared between the two groups.Result:After intervention,the levels of IL-4,IL-5,IL-8 and IL-13 in both groups were decreased,and those in the study group were lower than those in the control group(P<0.05).After intervention,FEV1,FEV1/FVC and PEF in both groups were increased,and those in the study group were higher than those in the control group(P<0.05).The disappearance time of cough and sputum in the study group were earlier than those in control group,hospital stay in the study group were shorter than those in the control group(P<0.05).Conclusion:The application of Beclometasone Dipropionate Inhalation Aerosol combined with Ketotifen in children with cough variant asthma can improve the inflammatory reaction and pulmonary function of children,alleviate clinical symptoms and shorten hospital stay.