气管内滴入肺表面活性物质联合呼吸机治疗新生儿呼吸窘迫综合征的效果

Effect of Intratracheal Drip of Pulmonary Surfactant Combined with Ventilator on Neonatal Respiratory Distress Syndrome

目的:探究气管内滴入肺表面活性物质联合呼吸机治疗新生儿呼吸窘迫综合征的效果及对氧合功能、肺换气功能的影响。方法:将2020年6月—2023年6月菏泽市牡丹人民医院收治的80例新生儿呼吸窘迫综合征患儿根据随机数字表法分为对照组和观察组,各40例。对照组采用呼吸机治疗,观察组在对照组的基础上行气管内滴入牛肺表面活性剂治疗。比较两组治疗总有效率、呼吸机应用时间、住院时间,以及治疗前后的血气分析指标[动脉血氧分压(PaO_(2))及动脉血二氧化碳分压(PaCO_(2))]、氧合功能指标[氧合指数(OI)及呼吸指数(RI)]及肺换气指标[肺泡-动脉氧分压差(PA-aDO_(2))及弥散指数]。结果:观察组治疗总有效率显著高于对照组,呼吸机应用时间及住院时间均显著短于对照组,差异均有统计学意义(P<0.05);治疗前两组血气分析指标、氧合功能指标及肺换气指标比较,差异均无统计学意义(P>0.05),治疗12、24、48 h后,观察组PaO_(2)、OI及弥散指数均显著高于对照组,PaCO_(2)、RI及PA-aDO_(2)均显著低于对照组,差异均有统计学意义(P<0.05)。结论:气管内滴入肺表面活性物质联合呼吸机治疗新生儿呼吸窘迫综合征的效果较好,且可显著改善患儿的氧合功能及肺换气功能。

Objective:To investigate the effect of intratracheal drip of pulmonary surfactant combined with ventilator on neonatal respiratory distress syndrome and its influence on oxygenation function and pulmonary gas exchange function.Method:A total of 80 children with neonatal respiratory distress syndrome admitted to Mudan People's Hospital of Heze City from June 2020 to June 2023 were divided into control group and observation group according to random number table method,with 40 cases in each group.The control group was treated with ventilator,and the observation group was treated with intratracheal drip of Calf Pulmonary Surfactant on the basis of the control group.The total effective rate,ventilator application time and hospital stay,before and after treatment of blood gas analysis indexes[arterial partial pressure of oxygen(PaO_(2))and arterial partial pressure of carbon dioxide(PaCO_(2))],oxygenation function indexes[oxygenation index(OI)and respiratory index(RI)]and pulmonary gas exchange indexes[alveolar-arterial oxygen partial pressure difference(PA-aDO_(2))and diffusion index]of two groups were compared.Result:The total effective rate of the observation group was significantly higher than that of the control group,and the ventilator application time and hospital stay were significantly shorter than those of the control group,the differences were statistically significant(P<0.05).There were no statistical significance in blood gas analysis indexes,oxygenation function indexes and pulmonary gas exchange indexes between two groups before treatment(P>0.05).After 12,24 and 48 h of treatment,PaO_(2),OI and diffusion index in the observation group were significantly higher than those in the control group,and PaCO_(2),RI and PA-aDO_(2) were significantly lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion:The effect of intratracheal drip of pulmonary surfactant combined with ventilator in the treatment of neonatal respiratory distress syndrome is better,and can significantly improve the oxygenation function and pulmonary gas exchange function of the children.