低剂量沙库巴曲缬沙坦钠联合酒石酸美托洛尔治疗扩张型心肌病心力衰竭的有效性

Efficacy of Low Dose Sacubitril Valsartan Sodium Combined with Metoprolol Tartrate in the Treatment of Heart Failure in Patients with Dilated Cardiomyopathy

目的:探讨低剂量沙库巴曲缬沙坦钠联合酒石酸美托洛尔治疗扩张型心肌病心力衰竭的有效性。方法:选取2021年1月—2023年1月新余钢铁集团有限公司中心医院收治的76例扩张型心肌病心力衰竭患者,随机分为对照组(n=36)、观察组(n=40)。对照组采用酒石酸美托洛尔治疗,观察组采用低剂量沙库巴曲缬沙坦钠联合酒石酸美托洛尔治疗。比较两组临床疗效、心功能指标、血清学指标及不良反应发生情况。结果:观察组治疗总有效率高于对照组(P<0.05)。治疗后,观察组左心室射血分数(LVEF)、每搏输出量(SV)水平均高于对照组,左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)及血清N-末端脑钠肽前体(NT-proBNP)、肌钙蛋白(cTnI)、肌酸激酶同工酶(CK-MB)水平均低于对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:低剂量沙库巴曲缬沙坦钠联合酒石酸美托洛尔治疗扩张型心肌病心力衰竭临床效果确切,能有效改善患者心功能及血清学指标,且未增加不良反应发生率。

Objective:To investigate the efficacy and effect of low dose Sacubitril Valsartan Sodium combined with Metoprolol Tartrate in the treatment of heart failure in patients with dilated cardiomyopathy.Method:A total of 76 patients with dilated cardiomyopathy and heart failure admitted to the Central Hospital of Xinyu Iron and Steel Group Co.,Ltd.from January 2021 to January 2023 were selected and randomly divided into control group(n=36)and observation group(n=40).The control group was treated with Metoprolol Tartrate,and the observation group was treated with low dose Sacubitril Valsartan Sodium combined with Metoprolol Tartrate.The clinical efficacy,cardiac function indexes,serological indexes and the occurrence of adverse reactions were compared between the two groups.Result:The total effective rate of observation group was higher than that of control group(P<0.05).After treatment,the left ventricular ejection fraction(LVEF)and stroke output(SV)levels in the observation group were higher than those in the control group,the levels of left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD)and serum N-terminal brain natriuretic peptide precursor(NT-proBNP),cardiac troponin I(cTnI)and creatine kinase-MB(CK-MB)were lower than those of control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Low dose of Sacubitril Valsartan Sodium combined with Metoprolol Tartrate has definite clinical efficacy in the treatment of heart failure in patients with dilated cardiomyopathy,which can effectively improve cardiac function and serological indexes without increasing the incidence of adverse reactions.