基于文献计量学的肾细胞癌治疗药物耐药相关研究热点与趋势分析

Research hotspots and future trends of drug resistance mechanism in treatment of renal cell carcinoma based on bibliometric analysis

目的分析肾细胞癌(RCC)治疗药物耐药相关研究现状,热点与发展趋势,为该领域研究提供参考。方法以Web of Science核心合集为数据来源获取RCC治疗药物耐药相关研究文献,利用CiteSpace软件进行关键词聚类和趋势分析,运用VOSviewer软件进行文献关键词共现网络分析。结果经筛选纳入RCC治疗药物耐药相关文献1392篇,包括靶向治疗药物耐药相关文献736篇,免疫治疗药物耐药文献158篇,化疗药物耐药文献369篇。RCC耐药领域研究整体随发布年份呈上升趋势,其中靶向治疗药物耐药研究占据主导地位,免疫治疗药物耐药是一个新兴研究方向。关键词整体指向RCC治疗药物耐药分子机制、潜在信号通路、靶向免疫联合治疗、指示生物标志物,以及新型治疗等。关键词和主题词演变提示,RCC靶向治疗药物耐药领域近年研究方向聚焦耐药新机制的探索以及多靶点药物的应用,免疫治疗药物耐药研究趋势表明靶向联合免疫治疗、肿瘤微环境,以及转移相关性为该领域主要研究方向,化疗药物耐药聚焦于药动学相关因素、多药耐药基因的参与,以及新机制的探索。结论为研究者准确把握肾细胞癌耐药领域研究现状及发展趋势提供参考。

Objective To systematically analyze the research hotspots and development trends of drug resistance mechanisms in renal cell carcinoma(RCC),and to provide a reference for research in this field.Methods The literature related to drug resistance in treatment of RCC was obtained from Web of Science core collection.CiteSpace software was used for keyword clustering and trend analysis,and VOSviewer software was used for keyword co-occurrence network analysis.Results In total,1392 literature were incorporated,including 736 regarding targeted therapy,158 in immunotherapy,and 369 in chemotherapy.The overall research trend in this field was on the rise,in which the research on targeted therapy resistance occupies a dominant position,and immunotherapy resistance was a new research direction.Key words in this field were focused on molecular mechanisms of drug resistance,potential signaling pathways,combination therapy,indicators,and novel therapy.The evolution of keywords and theme words suggests that the research tendency of RCC targeted therapy resistance in recent years focuses on the exploration of new mechanisms of drug resistance and the application of multi-target drugs.The research trend of immunotherapy resistance highlights combination therapy,tumor microenvironment,and metastasis correlation.The research trend of chemotherapy resistance focused on pharmacokinetic-related factors,multidrug resistance genes.Conclusion To provide references for researchers to accurately grasp the research status and development trend of drug resistance in RCC.