酪酸梭菌二联活菌散联合吹氧对新生儿尿布皮炎的效果研究

Effect of oxygen blowing combined with clostridium butyricum and bifidobacterium powders in neonatal diaper dermatitis

目的分析酪酸梭菌二联活菌散联合吹氧对新生儿尿布皮炎(DD)的临床疗效。方法回顾性分析2019年1月至2021年6月杭州师范大学附属医院儿科收治的新生儿DD患者资料。根据是否接受酪酸梭菌二联活菌散治疗分为对照组(吹氧)和试验组(吹氧联合酪酸梭菌二联活菌散)。研究主要疗效指标为治疗有效率,次要疗效指标为DD严重程度(新生儿皮疹量表评分、DD分度和皮损面积评分)、红斑消退时间、糜烂消退时间及痊愈时间。结果研究共纳入99例患者,试验组42例,对照组57例。试验组治疗有效率显著高于对照组(P<0.05)。DD严重程度方面,试验组丘疹及脓包评分、皮炎范围评分、红斑严重程度评分、皮肤损伤评分和皮损面积评分均显著低于对照组(P<0.05);试验组DD中度和重度比例低于对照组(P<0.05)。试验组红斑消退时间、糜烂消退时间和痊愈时间小于对照组(P<0.05)。结论酪酸梭菌二联活菌散联合吹氧可显著改善新生儿DD的临床效果,但其具体机制仍需探索。

Objective To explore the clinical efficacy of oxygen blowing combined with clostridium butyricum and bifidobacterium powders in neonatal diaper dermatitis(DD).Methods Data of neonatal DD patients admitted to the Department of Pediatrics of the Affiliated Hospital of Hangzhou Normal University from January 2019 to June 2021 were retrospectively analyzed.They were divided into the control group(oxygen blowing)and the experimental group(oxygen blowing combined with clostridium butyricum and bifidobacterium powders)according to whether or not they received clostridium butyricum and bifidobacterium powders treatment.The primary efficacy index of the study was the treatment efficiency,and the secondary efficacy indexes were the severity of DD(Neonatal Rash Scale score,DD score,and lesion area score),time to erythema resolution,time to vesicle resolution,and time to healing.Results A total of 99 patients were included in the study,with 42 in the experimental group and 57 in the control group.The treatment efficiency of the experimental group was significantly higher than that of the control group(P<0.05).With regard to the severity of DD,the papule and pustule scores,dermatitis extent scores,erythema severity scores,skin damage scores and lesion area scores of the experimental group were significantly lower than those of the control group(P<0.05);the proportions of moderate and severe syndrome in the experimental group were lower than those of the control group(P<0.05).The time for erythema to subside,the time for vesicles to subside and the time for healing were shorter in the experimental group than in the control group(P<0.05).Conclusion Oxygen blowing combined with clostridium butyricum and bifidobacterium powders can significantly improve the clinical effect of neonatal DD,but the specific mechanism still needs to be explored.