茵栀黄口服液对蓝光照射联合布拉氏酵母菌散治疗新生儿黄疸的增效作用

Synergistic effect of Yinzhihuang oral liquid on blue light irradiation combined with Saccharomyces boulardii powder in the treatment of neonatal jaundice

目的评估茵栀黄口服液对蓝光照射联合布拉氏酵母菌散治疗新生儿黄疸的增效作用。方法回顾性分析义乌市中心医院2022年1月至2024年1月收治的新生儿黄疸确诊患儿资料,根据治疗方案分为试验组与对照组。比较两组患儿心肌功能[肌酸激酶同工酶(CK-MB)、肌酸激酶(CK)、心肌钙蛋白I(cTnI)]、血气指标[氧分压(PaO_(2))、二氧化碳分压(PaCO_(2))、pH值]、症状改善情况、疗效及不良反应。结果研究共纳入180例患儿,每组各90例。试验组有效率高于对照组,且不良反应发生率低于对照组(P<0.05)。治疗后,两组患儿CK、CK-MB、cTnI、PaCO_(2)水平较治疗前降低,且试验组低于对照组(P<0.05);两组患儿pH值、PaO_(2)水平增加,且试验组高于对照组(P<0.05)。试验组各症状改善时间和日均大便次数均小于对照组(P<0.05)。结论茵栀黄口服液联合布拉氏酵母菌散能有效改善新生儿黄疸确诊患儿心肌功能,调节血气,提高患儿疗效,且安全性较高。

Objective To evaluate the synergistic effect of Yinzhihuang oral liquid on blue light irradiation combined with Saccharomyces boulardii powder in the treatment of neonatal jaundice.Methods The data of children with neonatal jaundice admitted to Yiwu Central Hospital from January 2022 to January 2024 were retrospectively analyzed.Patients were divided into the experimental group and the control group according to the treatment plans.The myocardial function[creatine kinase isoenzyme(CK-MB),creatine kinase(CK)and cardiac troponin I(cTnI)],blood gas indexes[partial pressure of oxygen(PaO_(2)),partial pressure of carbon dioxide(PaCO_(2))and pH value],symptom improvement,efficacy and incidence of adverse reactions were compared between the two groups.Results A total of 180 children were included in the study,with 90 in each group.The effective rate of the experimental group was higher than that of the control group,and the incidence of adverse reactions was lower than that of the control group(P<0.05).After treatment,the levels of CK,CK-MB,cTnI and PaCO_(2) in the two groups were lower than those before treatment,and the experimental group was lower than the control group(P<0.05);the levels of pH and PaO_(2) in the two groups increased,and the experimental group was higher than the control group(P<0.05).The improvement time of each symptom and the number of bowel movements per day in the experimental group were smaller than that in the control group(P<0.05).Conclusion Yinzhihuang oral liquid combined with Saccharomyces boulardii powder can effectively improve the myocardial function,regulate blood gas,improve the curative effect of children with neonatal jaundice,and is with good safety.