生物源性钙磷灰石尺寸引发的骨仿生层级演变及其骨凝血免疫效应

Hierarchical evolution of bone biomimicry and osteo-coagulo-immunomodulation induced by the size of biological hydroxyapatite

生物源性钙磷灰石(BHA)因良好的生物相容性和骨传导性,广泛应用于临床骨缺损的治疗中。基于临床应用中的骨缺损区适配原则,BHA具有尺寸多元性设计,然而不同尺寸对应着不同的骨仿生层级,随着尺寸变化,其具备的骨仿生层级随之演变,并通过骨凝血免疫调控影响骨修复再生进程,导致植骨结局不稳定。本文对BHA的尺寸效应进行回顾,通过分析天然骨多级结构,提出BHA尺寸引发骨仿生层级演变,仿生层级介导凝血免疫效应,并基于骨仿生层级及其骨凝血免疫效应,提出对不同尺寸BHA材料生物学效应的新认识及其生物学原理,为不同尺寸BHA材料的基础研发和临床应用提供理论基础。

Biological hydroxyapatite(BHA)is widely used in the treatment of clinical bone defects due to its good biocompatibility and osteoconductivity.The clinical application of mateiral size is based on the principle of bone defect area adaptation,which contributes to diversity of BHA sizes.However,different sizes correspond to different hierarchical levels of bone biomimicry.As the size changes,the bone biomimicry hierarchy evolves accordingly and influences the process of bone repair and regeneration through osteo-coagulo-immunomodulation,leading to unstable bone graft outcomes.Therefore,this paper reviews the size effect of clinical BHA,analyzes the multilevel structure of natural bone,proposes the evolution of bone biomimetic hierarchy triggered by the size of BHA,and further analyzes the size-media-ted osteo-coagulo-immunomodulation.Based on the hierarchical levels of bone and its osteo-coagulo-immunomodulation effect,we provide a new understanding of the biological principle of the size effect of biomaterials and a theoretical basis for the basic research and clinical application of different size BHA materials.