苏黄止咳胶囊联合盐酸西替利嗪治疗感冒后咳嗽的效果及对免疫平衡影响

Effect of Suhuang Zhike capsules combined with cetirizine hydrochloride tablets on post-cold cough and immunological balance

目的探讨苏黄止咳胶囊联合盐酸西替利嗪治疗感冒后咳嗽的效果及对免疫平衡的影响。方法选取2019年3月—2021年3月于我院就诊的52例感冒后咳嗽病人,根据病人用药情况分为对照组(苏黄止咳胶囊治疗)和观察组(苏黄止咳胶囊联合盐酸西替利嗪片治疗),每组26例。比较两组的咳嗽症状评分、视觉模拟评分法(VAS)评分、呼出气一氧化氮(FeNO)水平、CD4/CD8比值和淋巴细胞总数。结果观察组的治疗后咳嗽评分及其改善值均优于对照组,差异具有统计学意义(t=9.155~14.384,P<0.05)。观察组的治疗后VAS评分及其改善值均优于对照组(t=13.145、10.690,P<0.05)。观察组的治疗后FeNO水平及其改善值均优于对照组,差异具有统计学意义(t=24.386、8.125,P<0.05)。观察组的治疗后CD4/CD8比值和淋巴细胞总数及其改善值均优于对照组,差异具有统计学意义(t=13.265~24.419,P<0.05)。观察组治愈率和总有效率较对照组显著升高(χ^(2)=16.391、201.124,P<0.05)。结论苏黄止咳胶囊联合盐酸西替利嗪治疗对感冒后咳嗽病人具有显著疗效,能有效改善免疫平衡。

Objective To investigate the therapeutic effect of Suhuang Zhike capsules combined with cetirizine hydrochloride tablets in patients with post-cold cough and its effect on immunological balance.Methods A total of 52 patients with post-cold cough who visited our hospital from March 2019 to March 2021 were selected and divided into control group(treated with Suhuang Zhike capsules)and observation group(treated with Suhuang Zhike capsules combined with cetirizine hydrochloride tablets)based on their medications,with 26 patients in each group.The cough symptom score,visual analogue scale(VAS)score,fractional exhaled nitric oxide(FeNO),CD4/CD8 ratio,and total lymphocyte count were compared between the two groups.Results After treatment,compared with the control group,the observation group had significantly better cough score and its improvement value(t=9.155-14.384,P<0.05),VAS score and its improvement value(t=13.145,10.690,P<0.05),FeNO and its improvement value(t=24.386,8.125,P<0.05),and CD4/CD8 ratio and total lymphocyte count as well as their improvement values(t=13.265-24.419,P<0.05).The cure rate and overall response rate of the observation group were significantly higher than those of the control group(χ^(2)=16.391,201.124,P<0.05).Conclusion Suhuang Zhike capsules combined with cetirizine hydrochloride tablets have a significant therapeutic effect in patients with post-cold cough and effectively improve immunological balance.