小胶质细胞在创伤性颅脑损伤后神经炎症调控及疾病治疗中的研究进展

Recent advance in role of microglia in neuroinflammation regulation and disease treatment after traumatic brain injury

创伤性颅脑损伤(TBI)可引起一系列继发性改变,如神经元功能障碍、血脑屏障破坏、神经血管的继发性损伤、神经炎症等,甚至会有神经退行性疾病的发生。近几年研究发现小胶质细胞可通过其M1表型、M2表型的改变来调控TBI后长期的炎症和组织修复过程,影响TBI的进展。本文围绕TBI后小胶质细胞的作用、调控机制及相关治疗方面的研究进展进行综述,以期为TBI的治疗提供理论依据。

Traumatic brain injury(TBI)can cause a series of secondary changes,such as neuronal dysfunction,blood-brain barrier destruction,secondary neurovascular injury,neuroinflammation,and even neurodegenerative diseases.In recent years,studies have found that microglia can regulate the long-term inflammation and tissue repair process after TBI through the changes of M1 phenotype and M2 phenotype,affecting the TBI progress.Therefore,this article reviews the recent advance in role of microglia,regulatory mechanisms and related therapies of microglia after TBI,in order to provide some references for TBI treatment.