双歧杆菌三联活菌胶囊及乳果糖联合哌拉西林/他唑巴坦治疗肝硬化合并自发性细菌性腹膜炎的临床效果

Clinical effect of live combined Bifidobacterium,Lactobacillus and Enterococcus capsules and lactulose combined with piperacillin/tazobactam in the treatment of liver cirrhosis complicated with spontaneous bacterial peritonitis

目的探讨双歧杆菌三联活菌胶囊及乳果糖联合哌拉西林/他唑巴坦治疗肝硬化合并自发性细菌性腹膜炎(SBP)的效果。方法选取2021年3月至2023年4月收治的88例肝硬化合并SBP患者,将其随机分为对照组(44例,哌拉西林/他唑巴坦治疗)及观察组(44例,双歧杆菌三联活菌胶囊及乳果糖联合哌拉西林/他唑巴坦治疗)。比较两组的治疗效果。结果观察组的治疗总有效率高于对照组(P<0.05)。观察组的体温复常时间、腹部压痛消失时间、腹水常规检查正常时间及腹水消失时间短于对照组(P<0.05)。治疗1周后,观察组的肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)水平低于对照组,白细胞介素-10(IL-10)水平高于对照组(P<0.05)。治疗1周后,观察组的CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)及自然杀伤(NK)细胞高于对照组(P<0.05)。治疗1周后,观察组的谷丙转氨酶(ALT)、谷草转氨酶(AST)、γ-谷氨酰转肽酶(GGT)及总胆红素(TBIL)水平明显低于对照组(P<0.05)。结论双歧杆菌三联活菌胶囊及乳果糖联合哌拉西林/他唑巴坦可改善肝硬化合并SBP患者的临床症状,降低机体炎症反应。

Objective To investigate the effect of live combined Bifidobacterium,Lactobacillus and Enterococcus capsules and lactulose combined with piperacillin/tazobactam in the treatment of liver cirrhosis complicated with spontaneous bacterial peritonitis(SBP).Methods A total of 88 patients with liver cirrhosis complicated with SBP admitted from March 2021 to April 2023 were selected and randomly divided into control group(44 cases,treated with piperacillin/tazobactam)and observation group(44 cases,treated with live combined Bifidobacterium,Lactobacillus and Enterococcus capsules and lactulose combined with piperacillin/tazobactam).The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).The recovery time of body temperature,disappearance time of abdominal tenderness,normal time of routine examination of ascites and disappearance time of ascites in the observation group were shorter than those in the control group(P<0.05).After 1 week of treatment,the levels of tumor necrosis factor-α(TNF-α)and C-reactive protein(CRP)in the observation group were lower than those in the control group,and the level of interleukin-10(IL-10)was higher than that in the control group(P<0.05).After 1 week of treatment,the CD3^(+),CD4^(+),CD4^(+)/CD8^(+)and natural killer(NK)cells in the observation group were higher than those in the control group(P<0.05).After 1 week of treatment,the levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),γ-glutamyl transferase(GGT)and total bilirubin(TBIL)in the observation group were significantly lower than those in the control group(P<0.05).Conclusion Live combined Bifidobacterium,Lactobacillus and Enterococcus capsules and lactulose combined with piperacillin/tazobactam can improve the clinical symptoms of patients with liver cirrhosis and SBP,and reduce the bodys'inflammatory response.