依达拉奉联合血塞通治疗急性缺血性脑血管病的效果及对神经功能的影响

Effect of edaravone combined with Xuesaitong in the treatment of acute ischemic cerebrovascular disease and its influence on neurological function

目的探讨依达拉奉联合血塞通治疗急性缺血性脑血管病的效果及对神经功能的影响。方法选取2021年12月至2022年12月收治的80例急性缺血性脑血管病患者,按照随机数字表法将其分为对照组(n=40)和观察组(n=40)。对照组采用血塞通治疗,观察组在此基础上联合依达拉奉治疗。比较两组的临床疗效、脑循环动力学指标、氧化应激因子水平、神经功能缺损程度、日常生活活动能力及不良反应发生情况。结果观察组的治疗总有效率为95.00%,高于对照组的80.00%(P<0.05)。治疗后,两组的颈动脉最小血流速度(V_(min))、最小血流量(Q_(min))明显升高,脑血管阻力(R)明显降低,且观察组优于对照组(P<0.05)。治疗后,两组的中枢神经特异蛋白(S100β)、神经元特异性烯醇化酶(NSE)水平显著降低,超氧化物歧化酶(SOD)水平显著升高,且观察组优于对照组(P<0.05)。治疗后,两组的美国国立卫生研究院卒中量表(NIHSS)评分显著降低,日常生活活动能力量表(ADL)评分显著升高,且观察组优于对照组(P<0.05)。两组的不良反应总发生率无显著差异(P>0.05)。结论依达拉奉联合血塞通治疗急性缺血性脑血管病患者的效果确切,可改善脑循环动力学,降低氧化应激反应,减轻神经功能损伤程度,提升日常生活活动能力,安全性高。

Objective To investigate the effect of edaravone combined with Xuesaitong in the treatment of acute ischemic cerebrovascular disease and its influence on neurological function.Methods Eighty patients with acute ischemic cerebrovascular disease admitted from December 2021 to December 2022 were selected and divided into control group(n=40)and observation group(n=40)according to the random number table method.The control group was treated with Xuesaitong,and the observation group was treated with edaravone on this basis.The clinical efficacy,cerebral circulation dynamics indexes,oxidative stress factors level,neurological deficit degree,activities of daily living and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 95.00%,which was higher than 80.00%in the control group(P<0.05).After treatment,the _(min)imum blood flow velocity(V_(min))and _(min)imum blood flow(Q_(min))of carotid artery in the two groups significantly increased,and the cerebrovascular resistance(R)significantly decreased,and those in the observation group were better than the control group(P<0.05).After treatment,the levels of soluble protein-100β(S100β)and neuron specific enolase(NSE)in the two groups significantly decreased,the level of superoxide dismutase(SOD)significantly increased,and those in the observation group were better than the control group(P<0.05).After treatment,the National Institute of Health Stroke Scale(NIHSS)score of the two groups significantly decreased,the Activities of Daily Living(ADL)score significantly increased,and those of the observation group were better than the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Edaravone combined with Xuesaitong in the treatment of patients with acute ischemic cerebrovascular disease has a definite effect.It can improve cerebral circulation dynamics,decrease oxidative stress response,reduce neurological damage degree,and improve activities of daily living with high safety.