硝苯地平控释片联合贝那普利治疗老年原发性高血压的效果及对血管内皮功能、ALD及TGF-β1水平的影响

Effect of nifedipine controlled-release tablets combined with benazepril in the treatment of elderly patients with primary hypertension and its influences on vascular endothelial function,ALD and TGF-β1 levels

目的探讨硝苯地平控释片联合贝那普利治疗老年原发性高血压的效果及对血管内皮功能、醛固酮(ALD)及转化生长因子-β1(TGF-β1)水平的影响。方法选取2020年1月至2023年1月我院收治的80例老年原发性高血压患者,以随机数字表法将其分为对照组(40例,贝那普利)和观察组(40例,硝苯地平控释片联合贝那普利)。比较两组的治疗效果。结果观察组的治疗总有效率高于对照组(P<0.05)。治疗后,观察组的内皮素-1(ET-1)、神经肽Y(NPY)水平低于对照组,一氧化氮(NO)水平高于对照组(P<0.05)。治疗后,观察组的ALD、TGF-β1水平低于对照组(P<0.05)。两组的不良反应总发生率无明显差异(P>0.05)。结论硝苯地平控释片联合贝那普利治疗老年原发性高血压的效果显著,可改善患者的血管内皮功能,下调ALD、TGF-β1水平,且安全性高,值得推广。

Objective To investigate the effect of nifedipine controlled-release tablets combined with benazepril in the treatment of elderly patients with primary hypertension and its influences on vascular endothelial function,aldosterone(ALD)and transforming growth factor-β1(TGF-β1)levels.Methods A total of 80 elderly patients with primary hypertension admitted in our hospital from January 2020 to January 2023 were selected and divided into control group(40 cases,benazepril)and observation group(40 cases,nifedipine controlled-release tablets combined with benazepril)by random number table method.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the levels of endothelin-1(ET-1)and neuropeptide Y(NPY)in the observation group were lower than those in the control group,and the level of nitric oxide(NO)was higher than that in the control group(P<0.05).After treatment,the levels of ALD and TGF-β1 in the observation group were lower than those in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The nifedipine controlled-release tablets combined with benazepril in the treatment of elderly patients with primary hypertension has a significant effect.It can improve the vascular endothelial function of patients,down-regulate the levels of ALD and TGF-β1,and has high safety,which is worthy of promotion.