摘要
目的探讨鼓室内注射地塞米松、盐酸氨溴索联合耳内镜下鼓膜置管术治疗分泌性中耳炎的临床效果。方法选取2020年10月至2022年10月我院收治的80例分泌性中耳炎患者作为研究对象,以随机数字表法将其分为对照组(耳内镜下鼓膜置管术)和观察组(鼓室内注射地塞米松、盐酸氨溴索联合耳内镜下鼓膜置管术),各40例。比较两组的治疗效果。结果观察组的治疗总有效率高于对照组(P<0.05)。治疗后,观察组的鼓室压、语频气导听阈优于对照组(P<0.05)。治疗后,观察组的咽鼓管功能障碍问卷-7(ETDQ-7)评分低于对照组,咽鼓管功能评分(ETS)评分高于对照组(P<0.05)。治疗后,观察组的白细胞介素-2(IL-2)、白细胞介素-10(IL-10)、干扰素-γ(IFN-γ)水平低于对照组(P<0.05)。治疗后,观察组的透明质酸(HA)、血小板活化因子(PAF)水平低于对照组,纤维连接蛋白(FN)水平高于对照组(P<0.05)。结论鼓室内注射地塞米松、盐酸氨溴索联合耳内镜下鼓膜置管术治疗分泌性中耳炎效果满意,可改善咽鼓管功能,减轻机体炎症反应,降低血管通透性。
Objective To investigate the clinical effect of intratympanic injection of dexamethasone and ambroxol hydrochloride combined with endoscopic tympanic membrane catheterization in the treatment of secretory otitis media.Methods A total of 80 patients with secretory otitis media admitted in our hospital from October 2020 to October 2022 were selected as the research objects.The patients were divided into control group(endoscopic tympanic membrane catheterization)and observation group(intratympanic injection of dexamethasone and ambroxol hydrochloride combined with endoscopic tympanic membrane catheterization)by random number table method,with 40 cases in each group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the tympanic pressure and speech frequency air conduction hearing threshold in the observation group were better than those in the control group(P<0.05).After treatment,the Eustachian Tube Dysfunction Questionnaire-7(ETDQ-7)score in the observation group was lower than that in the control group,and the Eustachian Tube Score(ETS)score was higher than that in the control group(P<0.05).After treatment,the levels of interleukin-2(IL-2),interleukin-10(IL-10)and interferon-γ(IFN-γ)in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of hyaluronic acid(HA)and platelet activating factor(PAF)in the observation group were lower than those in the control group,and the level of fibronectin(FN)was higher than that in the control group(P<0.05).Conclusion Intratympanic injection of dexamethasone and ambroxol hydrochloride combined with endoscopic tympanic membrane catheterization is effective in the treatment of secretory otitis media.It can improve the function of eustachian tube,reduce the body's inflammatory response and decrease vascular permeability.
作者
王苑
陈志惠
庞礴
黄窅东
WANG Yuan;CHEN Zhihui;PANG Bo;HUANG Yaodong(Hanzhong Central Hospital,Hanzhong 723000,China)
出处
《临床医学研究与实践》
2024年第33期135-138,共4页
Clinical Research and Practice
关键词
内镜
鼓膜置管术
鼓室内注射
地塞米松
盐酸氨溴索
分泌性中耳炎
endotoscope
tympanic membrane catheterization
intratympanic injection
dexamethasone
ambroxol hydrochloride
secretory otitis media