基于蒙特梭利法的干预对慢性粒细胞白血病患者生活质量的影响

Effect of Montessori based intervention on quality of life in patients with chronic myelocytic leukemia

目的探讨基于蒙特梭利法的干预对慢性粒细胞白血病(CML)患者生活质量的影响。方法将60例CML患者根据干预方式的不同分为对照组(n=29,常规干预)和观察组(n=31,常规干预+基于蒙特梭利法的干预)。比较两组患者睡眠质量[匹兹堡睡眠质量指数(PSQI)]、负性情绪[焦虑自评量表(SAS)和抑郁自评量表(SDS)]、不良反应发生情况和生活质量[白血病患者生命质量测定量表(FACT-Leu)]。结果干预后,两组患者PSQI、SAS、SDS量表评分均较干预前降低,且观察组患者PSQI、SAS、SDS量表评分均低于对照组,差异均有统计学意义(P﹤0.05)。观察组患者非血液学不良反应总发生率低于对照组,差异有统计学意义(P﹤0.05)。干预后,两组患者生理、社会/家庭、情感、认知、白血病特异模块评分及FACT-Leu总分均较干预前升高,且观察组患者生理、社会/家庭、情感、认知、白血病特异模块评分及FACT-Leu总分均高于对照组,差异均有统计学意义(P﹤0.05)。结论基于蒙特梭利法的干预可减轻CML患者焦虑抑郁情绪,改善睡眠质量,减少非血液学不良反应,进而提高患者生活质量。

Objective To investigate the effect of Montessori based intervention on quality of life in patients with chronic myelocytic leukemia(CML).Method A total of 60 CML patients were divided into control group(n=29,conventional intervention)and observation group(n=31,conventional intervention+Montessori based intervention)according to different intervention methods.Sleep quality[Pittsburgh sleep quality index(PSQI)],negative emotions[self-rating anxiety scale(SAS)and self-rating depression scale(SDS)],incidence of adverse reactions and quality of life[functional assessment of cancer therapy-leukemia(FACT-Leu)]were compared between the two groups.Result After intervention,the scores of PSQI,SAS and SDS in two groups were lower than those before intervention,and the scores of PSQI,SAS and SDS in observation group were lower than those in control group,the differences were statistically significant(P<0.05).The total incidence of non-hematological adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).After intervention,the scores of physiological,social/family,emotion,cognition,leukemia-specific module and FACT-Leu total scores of both groups were higher than those before intervention,the scores of physiology,society/family,emotion,cognition,leukemia-specific module and FACTLeu total score in observation group were higher than those in control group,and the differences were statistically significant(P<0.05).Conclusion Montessori based intervention can reduce anxiety and depression in CML patients,improve sleep quality,reduce non-hematological adverse reactions,and improve the quality of life.