肠胃清汤剂联合奥沙利铂+卡培他滨在晚期结直肠癌患者中的应用效果

Application effect of Changweiqing decoction combined with oxaliplatin+capecitabine in patients with advanced colorectal cancer

目的探讨肠胃清汤剂联合奥沙利铂+卡培他滨在晚期结直肠癌(CRC)患者中的应用效果。方法根据治疗方式的不同将60例晚期CRC患者分为对照组(28例)和观察组(32例),对照组患者接受奥沙利铂+卡培他滨治疗,观察组患者在对照组的基础上接受肠胃清汤剂治疗。比较两组患者肠道菌群数量、炎性因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]水平、生活质量[卡氏功能状态(KPS)评分]及不良反应发生情况。结果治疗后,两组患者TNF-α、IL-6水平均低于本组治疗前,观察组患者TNF-α、IL-6水平均低于对照组,差异均有统计学意义(P﹤0.05)。治疗后,观察组患者肠球菌、链球菌数量均少于对照组,双歧杆菌、乳杆菌数量均多于对照组,KPS评分高于对照组,差异均有统计学意义(P﹤0.05)。观察组患者的不良反应总发生率为18.75%,明显低于对照组患者的57.14%,差异有统计学意义(P﹤0.01)。结论肠胃清汤剂联合奥沙利铂+卡培他滨治疗晚期CRC患者,可有效维持肠道菌群微生物稳态,缓解炎症反应,减少不良反应,提高生活质量。

Objective To investigate the application effect of Changweiqing decoction combined with oxaliplatin+capecitabine in patients with advanced colorectal cancer(CRC).Method According to the different treatment methods,60 patients with advanced CRC were divided into control group(28 cases)and observation group(32 cases).The control group received oxaliplatin+capecitabine treatment,and the observation group received Changweiqing decoction on the basis of the control group.The number of intestinal flora,inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)]levels,quality of life[Karnofsky performance status(KPS)score]and occurrence of adverse reactions of the two groups were compared.Result After treatment,the levels of TNF-αand IL-6 in two groups were lower than those before treatment,and the levels of TNF-αand IL-6 in observation group were lower than those in control group,the differences were statistically significant(P<0.05).After treatment,the numbers of enterococcus and streptococcus in observation group were less than those in control group,the numbers of bifidobacterium and lactobacillus were more than those in control group,and the KPS score was higher than that in control group,the differences were statistically significant(P<0.05).The total incidence of adverse reactions in observation group was 18.75%,which was significantly lower than 57.14%in control group,and the difference was statistically significant(P<0.01).Conclusion Changweiqing decoction combined with oxaliplatin+capecitabine can effectively maintain the homeostasis of intestinal microbiota,relieve inflammation,reduce adverse reactions,and improve quality of life in patients with advanced CRC.