中医肿瘤实验动物模型研究现状与展望

Research Status and Prospect of Experimental Animal Model of Tumor in Traditional Chinese Medicine

恶性肿瘤严重危害人类的生命和健康,肿瘤实验动物模型是研究肿瘤发病机制和筛选药物的重要工具。中医药在防治肿瘤中发挥了重要作用,但因其有效成分复杂,调控靶点众多,作用通路广泛,亟待更深入的研究来阐明中医药的抗癌机制。中医肿瘤证候动物模型能够模拟肿瘤患者的临床证候特点,是中医药抗肿瘤机制现代化研究的基石。本文对中医肿瘤实验动物模型及中医肿瘤证候动物模型的最新研究现状进行了综述并作出展望。

Malignant tumor seriously endangers human life and health,and experimental animal model of tumor is an important tool for studying the pathogenesis of tumor and screening drug.Traditional Chinese medicine(TCM)plays an important role in the prevention and treatment of tumor,but due to the complexity of its active ingredients,numerous regulatory targets,and wide range of action pathways,more in-depth studies are urgently needed to elucidate the anti-cancer mechanism of TCM.Animal model of TCM tumor syndrome can simulate the clinical characteristics of tumor patients,which is the cornerstone of modern research on the anti-tumor mechanism of TCM.This paper reviewed and made the prospect on the latest research status of experimental animal model of TCM tumor and animal model of TCM tumor syndrome.