肺部微生物组与肺癌发生、发展和治疗的关系研究进展

Progress in the relationship between the lung microbiome and the occurrence,development and treatment of lung cancer

肺部曾经被认为是无菌的,如今被证实存在一定的微生物定植,并且这些微生物在呼吸系统疾病的发病机制及治疗方面发挥着重要作用。肺癌作为世界第一大癌症,是由机体和环境因素之间相互作用引起的复杂疾病,在于大多数患者被诊断时已为晚期,病死率高。越来越多的证据表明,不同的肺部微生物组特征能够用于早期识别肺癌,并且对肺癌的发生、发展和治疗有一定的指导作用。本综述概括总结了肺部微生物与肺癌的关系、肺癌患者的肺部微生物特征、微生物在肺癌治疗中的应用前景等,以期为肺部微生物组作为新兴的生物标志物可对肺癌的诊治提供新思路,同时为今后肺癌微生物组的研究方向提出展望。

The lung was once thought to be sterile,but it is now confirmed to have a certain colonization of microorganisms,playing an important role in the pathogenesis and treatment of respiratory system diseases.Lung cancer,as the world's leading cancer,is a complex disease caused by the interaction of host and environmental factors.Its terrifying aspect is that most patients are diagnosed at a late stage,with a high mortality rate.Increasing evidence suggests that different characteristics of the lung microbiota can identify lung cancer early and have a certain guiding role in the occurrence,development,and treatment of lung cancer.In this review,we summarize the relationship between lung microbiota and lung cancer,characteristic of pulmonary microorganisms in patients with lung cancer,application prospect of microorganisms in the treatment of lung cancer.We hope that the lung microbiota,as an emerging biological marker,can provide new ideas for the diagnosis and treatment of lung cancer,and also propose prospects for future research directions on the lung cancer microbiota.