阿卡波糖在糖尿病合并消化道出血患者术后的应用价值

Application Value of Acarbose in Postoperative Diabetic Patients with Gastrointestinal Bleeding

目的分析阿卡波糖在糖尿病合并消化道出血患者术后的应用价值。方法回顾性选取2023年3月—2024年5月泉州市第一医院收治的110例糖尿病合并消化道出血患者的临床资料,根据术后降糖治疗方式不同分为两组,各55例。对照组进行二甲双胍治疗,研究组进行二甲双胍联合阿卡波糖治疗。对比两组血糖指标、胰岛功能、血液流变学指标水平。结果治疗后,研究组糖化血红蛋白、空腹血糖、餐后2 h血糖水平均低于对照组,差异有统计学意义(P均<0.05)。治疗后,研究组空腹胰岛素水平、胰岛β细胞功能指数、胰岛素抵抗指数均优于对照组,差异有统计学意义(P均<0.05)。治疗后,研究组全血黏度低切、血液黏度、红细胞压积水平均低于对照组,差异有统计学意义(P均<0.05)。结论糖尿病合并消化道出血患者术后应用阿卡波糖能够降低血糖水平,改善胰岛素水平与血液流变学指标,促进糖尿病及其合并症的康复。

Objective To analyze the postoperative application value of acarbose in diabetic patients with gastrointestinal bleeding.Methods The clinical data of 110 patients with diabetes mellitus complicated with gastrointestinal bleeding admitted to Quanzhou First Hospital from March 2023 to May 2024 were retrospectively selected.They were divided into two groups according to different postoperative hypoglycemic treatment methods,with 55 cases in each group.The control group was treated with metformin,and the study group was treated with metformin combined with acarbose.Blood glucose indexes,islet function and hemorheology indexes were compared between the two groups.Results After treatment,the levels of glycated hemoglobin A1c,fasting blood glucose and 2-hour postprandial blood glucose in the study group were lower than those in the control group,and the differences were statistically significant(all P<0.05).After treatment,fasting insulin level,isletβ-cell function index and insulin resistance index of the study group were better than those of the control group,and the differences were statistically significant(all P<0.05).After treatment,the whole blood viscosity low shear,blood viscosity and hematocrit in the study group were lower than those in the control group,and the differences were statistically significant(all P<0.05).Conclusion Postoperative application of acarbose in patients with diabetes mellitus complicated with gastrointestinal bleeding can reduce blood glucose level,improve insulin level and hemorheological indexes,and promote the rehabilitation of diabetes mellitus and its complications.