基于数据挖掘的中医药治疗石淋的用药规律分析

An analysis of medication rules of traditional Chinese medicine in the treatment of urethral calculus based on data mining

目的:通过数据挖掘及分析探讨中医药治疗泌尿系结石的临床运用现况及规律。方法:系统搜集中国知网、万方数据知识服务平台、维普等数据库自建库至2023年10月中医药治疗石淋的临床研究文献,运用Microsoft Excel进行规范化统计,并将规范化后的药方信息输入“中医传承辅助平台(V2.5)”,对用药频次、性味归经、组方规律和新处方进行分析,总结并研究中医药治疗石淋的用药规律。结果:共纳入相关方剂511首,涉及中药266味,其中频次≥30次的有42味,用药以利湿通淋为主,性味多寒、平、温,主要归膀胱经、肝经、肾经。常见药对包括海金沙-金钱草、鸡内金-金钱草、鸡内金-海金沙等。置信度较高的药组为鸡内金,海金沙,车前子→金钱草;鸡内金,海金沙,石韦→金钱草;海金沙,车前子→金钱草等。重组18首新方。结论:中医药治疗石淋以利湿通淋药物为主,中药优选金钱草、海金沙、鸡内金、车前子、石韦、滑石、牛膝,可为临床诊疗提供一定参考。

Objective:To explore the clinical application status and medication rule of traditional Chinese medicine in the treatment of urethral calculus through data mining and analysis.Methods:The clinical research literature on treating urethral calculus in TCM was systematically collected from CNKI,Wanfang Data,CQVIP and other databases from inception to October 2023,and standardized statistics were carried out by Microsoft Excel.After entering the standardized prescription data into TCM inheritance assistance system(V2.5),the medication frequency,medicinal property and flavor,composition rule and new prescriptions were analyzed to summarize and study the medication rules of TCM.Results:A total of 511 related prescriptions were selected,involving 266 Chinese medicines,of which 42 were used more than 30 times.Dispelling dampness and treating stranguria medicines were mainly used,the medicinal properties and tastes were mainly cold,moderate and warm,and most of them were attributed to bladder meridian,liver meridian and kidney meridian.The common drug pairs included Haijinsha(Lygodium japonicum)-Jinqiancao(Lysimachia),Ji’neijin(Membrane of chicken gizzard)-Jinqiancao,Ji’neijin-Haijinsha,etc..The drug groups with higher confidence were Ji’neijin,Haijinsha,Cheqianzi(Semen Plantaginis)→Jinqiancao;Ji’neijin,Haijinsha,Shiwei(Folium Pyrrosiae)→Jinqiancao;Haijinsha,Cheqianzi→Jinqiancao.Finally,there were 17 new prescriptions.Conclusion:Dispelling dampness and treating stranguria medicines are main used in the treatment of urethral calculus in TCM,and it is preferred to choose Chinese medicines such as Jinqiancao,Haijinsha,Ji’neijin,Cheqianzi,Shiwei,Huashi,Niuxi(Radix Achyranthis Bidentatae),etc.,which can provide certain reference for the clinical diagnosis and treatment of this disease.