基于R语言数据挖掘技术探讨裴正学教授治疗肺癌的用药规律及临床经验

The medication rule and clinical experience of Professor PEI Zhengxue in treating lung cancer based on R language data mining technology

目的:通过对裴正学教授治疗肺癌的门诊处方进行收集、整理及回顾性分析,归纳及探讨裴正学教授治疗肺癌的用药特点及组方规律,总结出其用药经验,为继承及发扬裴老的学术思想奠定坚实的基础。方法:收集2015年1月-2020年12月裴正学教授治疗肺癌患者的564张门诊处方,利用R语言进行数据挖掘,分析裴正学教授治疗肺癌的用药频次、关联规则,总结其治疗肺癌的用药规律及用药经验。结果:通过对收集的564张门诊处方进行分析,用药频次居前10位的药物为甘草、半夏、茯苓、苦杏仁、陈皮、桔梗、紫苏叶、枳壳、前胡、黄芩;通过关联规则、聚类分析得出,以杏苏散为主的核心方剂为裴正学教授治疗肺癌的基本方剂,对其并发症的治疗处方则为冠心病2号、四逆散、癌症五味消毒饮的组合。结论:通过对裴正学教授临床用药的分析统计,可见裴正学教授在治疗肺癌时注重分期论治,宣降肺气、培土生金贯穿治疗始终,重视肝、脾、肾三脏,擅长用活血化瘀法攻补兼施,遣方不拘一格,中晚期肺癌以扶正固本为其治疗大法,在临床上取得了一定的疗效。

Objective:To summarize and discuss the medication characteristics and prescription rules of Professor PEI Zhengxue in the treatment of lung cancer through the collection,collation and retrospective analysis of outpatient prescriptions on lung cancer of the professor,so as to summarize the medication experience,and lay a solid foundation for inheriting and developing the academic thought of the professor.Methods:After collecting 564 outpatient prescriptions on lung cancer of Professor PEI Zhengxue from January 2015 to December 2020,R language was used for data mining to analyze the drug used frequency and association rules in the treatment of lung cancer by Professor PEI Zhengxue,so as to summarize the medication rules and medication experience of the professor in the treatment of lung cancer.Results:The results of the analysis of 564 collected outpatient prescriptions showed that the top ten drugs with high drug frequency were Gancao(Radix Glycyrrhizae),Banxia(Rhizoma Pinelliae),Fuling(Poria),Kuxingren(Semen Armeniacae Amarum),Chenpi(Pericarpium Citri Reticulatae),Jiegeng(Radix Platycodonis),Zisuye(Folium Perillae),Zhiqiao(Fructus Aurantii),Qianhu(Radix Peucedani),and Huangqin(Radix Scutellariae).Through association rules and cluster analysis,it was concluded that Xingsu San(杏苏散)as the main composition of the core prescription was the basic prescription for the treatment of lung cancer by Professor PEI Zhengxue,and the prescription for its complications was the combination of coronary heart disease NO.2,Sini San(四逆散),and Aizheng Wuwei Xiaodu Yin(癌症五味消毒饮).Conclusion:In terms of the treatment of lung cancer,Professor PEI Zhengxue pays attention to the Clinical Journal of Chinese Medicine 2024-124-Vol.(16)No.29 stage of treatment,and the method of releasing lung Qi(气)to cultivate soil and produce gold is carried out throughout the treatment period.The professor attaches great importance to the liver,spleen and kidneys,and is good at both attacking and tonifying by the method of activating blood circulation and removing stasis.The professor does not stick to one style of prescription.In the treatment of middle and advanced lung cancer,the main method is to strengthen and consolidate body resistance,which has achieved certain clinical curative effects.