恩格列净、替格瑞洛联合二甲双胍治疗糖尿病合并稳定型心绞痛的作用研究

Study on the Effect of Empagliflozin,Ticagrelor Combined with Metformin in Treating Diabetes Mellitus Complicated with Stable Angina Pectoris

目的探究恩格列净、替格瑞洛联合二甲双胍治疗糖尿病合并稳定型心绞痛的作用。方法选取2023年1月—2024年3月海南省第二人民医院收治的106例糖尿病合并稳定型心绞痛患者作为研究对象,按照治疗方法的不同分为两组,各53例。两组均接受常规治疗,对照组在常规治疗基础上口服替格瑞洛,研究组在对照组基础上口服恩格列净。对比两组空腹血糖、餐后2 h血糖、血浆脑钠肽、糖化血红蛋白水平以及心绞痛症状发生情况。结果治疗前,两组空腹血糖、餐后2 h血糖、血浆脑钠肽、糖化血红蛋白水平以及心绞痛症状发生情况对比,差异无统计学意义(P均>0.05)。治疗3个月,研究组空腹血糖、餐后2 h血糖、血浆脑钠肽、糖化血红蛋白水平均低于对照组,差异有统计学意义(P均<0.05)。治疗3个月,研究组心电图中ST段异常及缺血型T波发生率均低于对照组,差异有统计学意义(P均<0.05)。结论恩格列净、替格瑞洛联合二甲双胍治疗糖尿病合并稳定型心绞痛,能够改善患者临床指标,降低血糖水平,改善心绞痛症状。

Objective To explore the effect of empagliflozin,ticagrelor combined with metformin in the treatment of diabetes mellitus complicated with stable angina pectoris.Methods A total of 106 patients with diabetes mellitus complicated with stable angina pectoris admitted to Hainan Second People's Hospital from January 2023 to March 2024 were selected as the study subjects.They were divided into two groups according to different treatment methods,53 cases in each group.Both groups received conventional treatment.The control group received oral ticagrelor on the basis of conventional treatment,and the study group received oral empagliflozin on the basis of the control group.The levels of fasting plasma glucose,2-hour postprandial plasma glucose,plasma brain natriuretic peptide,glycated hemoglobin A1c and the occurrence of angina pectoris were compared between the two groups.Results Before treatment,there was no significant difference in fasting plasma glucose,2-hour postprandial plasma glucose,plasma brain natriuretic peptide,glycated hemoglobin A1c levels and angina pectoris symptoms between the two groups(all P>0.05).After 3 months of treatment,the levels of fasting plasma glucose,2-hour postprandial plasma glucose,plasma brain natriuretic peptide and glycated hemoglobin A1c in the study group were lower than those in the control group,and the differences were statistically significant(all P<0.05).After 3 months of treatment,the incidence of ST segment abnormality and ischemic T wave in the study group were lower than those in the control group,and the differences were statistically significant(both P<0.05).Conclusion Empagliflozin,ticagrelor combined with metformin in the treatment of diabetes mellitus complicated with stable angina pectoris can improve the clinical indicators of patients,reduce blood glucose levels,and improve the symptoms of angina pectoris.