艾司氯胺酮镇痛治疗在术后疼痛管理中的应用效果评估

Evaluation of the Efficacy of Esketamine Analgesic Therapy in Postopera⁃tive Pain Management

目的研究艾司氯胺酮镇痛治疗在术后疼痛管理中的应用效果。方法非随机选取苏州市第九人民医院于2022年7月—2023年12月收治的90例手术治疗患者为研究对象,按照麻醉方案不同分为两组,每组45例,对照组实施舒芬太尼麻醉,观察组实施舒芬太尼+艾司氯胺酮麻醉。比较两组术后的数字疼痛分级法(Numerical Rating Scale,NRS)评分、镇痛泵应用相关情况、不良反应发生情况。结果观察组术后的NRS评分低于对照组,差异有统计学意义(P均<0.05)。观察组术后24 h舒芬太尼使用量、首次按压镇痛泵时间、术后24 h实际按压次数、术后24 h有效按压次数均低于对照组,差异有统计学意义(P均<0.05)。观察组的不良反应发生率为4.44%(2/45),低于对照组的22.22%(10/45),差异有统计学意义(χ^(2)=6.154,P<0.05)。结论艾司氯胺应用于术后疼痛管理中可取得较好的镇痛效果,不良反应发生率较低。

Objective To study the effect of esketamine analgesia in postoperative pain management.Methods A total of ninety patients with surgical treatment admitted to the Ninth People′s Hospital of Suzhou from July 2022 to December 2023 were non-randomly selected as the study objects.They were divided into two groups according to different anesthesia programs,forty-five cases in each group.The control group received sufentanil anesthesia,and the observation group received sufentanil anesthesia plus esketamine anesthesia.Numerical Rating Scale(NRS)scores,application of analgesic pump related conditions and occurrence of adverse reactions were compared between the two groups.Results The NRS score of the observation group was lower than that of the control group,and the differences were statistically significant(all P<0.05).The amount of sufentanil used 24 h after surgery,the time of first pressing the analgesic pump,the actual times of pressing 24 h after surgery,and the effective times of pressing 24 h after surgery in the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).The incidence of adverse reactions in the observation group was 4.44%(2/45),which was lower than 22.22%(10/45)in the control group,and the difference was statistically significant(χ2=6.154,P<0.05).Conclusion Esclomide can achieve better analgesic effect and lower incidence of adverse reactions in postoperative pain management.