氨磺必利联合利培酮对首发性精神分裂症患者内分泌功能的影响

Effect of Amisulpride Combined with Risperidone on Endocrine Function in Patients with First-Episode Schizophrenia

目的 探讨首发性精神分裂症患者采取氨磺必利联合利培酮治疗的效果。方法 回顾性选取2020年1月—2023年10月海淀区心理康复医院收治的64例首发性精神分裂症患者的临床资料,将其按照治疗方案分为两组,各32例。参照组采用利培酮治疗,研究组采用氨磺必利与利培酮联合治疗。对比两组患者的阳性与阴性综合征量表(Positive and Negative Syndrome Scale, PANSS)评分、内分泌功能指标与不良反应。结果治疗后,研究组PANSS总评分为(47.65±3.42)分,低于参照组的(51.19±4.23)分,差异有统计学意义(t=3.775,P<0.05);两组患者的内分泌功能指标水平高于治疗前,差异有统计学意义(P均<0.05),但研究组与参照组对比,差异无统计学意义(P均>0.05);两组患者的不良反应发生率对比,差异无统计学意义(P>0.05)。结论 对于首发性精神分裂症患者,在利培酮基础上加用氨磺必利能够有效促进症状改善,且未对内分泌功能造成明显影响,用药风险低,值得临床借鉴。

Objective To investigate the effect of amisulpride combined with risperidone in the treatment of patients with first-episode schizophrenia.Methods The clinical data of sixty-four patients with first-episode schizophrenia admitted to Haidian District Mental Rehabilitation Hospital from January 2020 to October 2023 were retrospectively selected and divided into two groups according to the treatment plan,with thirty-two cases in each group.The reference group was treated with risperidone,and the study group was treated with amisulpride combined with risperidone.The Positive and Negative Syndrome Scale(PANSS)scores,endocrine function indexes and adverse reactions were compared between the two groups.Results After treatment,the PANSS total score of the study group was 47.65±3.42,which was lower than 51.19±4.23 of the reference group,the difference was statistically significant(t=3.775,P<0.05);The levels of endocrine function indicators in the two groups were higher than those before treatment,and the difference was statistically significant(all P<0.05),but there was no significant difference between the study group and the reference group(all P>0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion For patients with first-episode schizophrenia,the addition of amisulpride on the basis of risperidone can effectively promote the improvement of symptoms,without significant effects on endocrine function,and the risk of medication is low,which is worthy of clinical reference.