依达拉奉与氯吡格雷联合应用于急性脑梗死治疗中的效果分析

Efficacy of Edaravone Combined with Clopidogrel in the Treatment of Acute Cerebral Infarction

目的探讨依达拉奉与氯吡格雷联合应用于急性脑梗死治疗中的效果。方法非随机选取2022年1月—2023年10月山东省聊城市妇幼保健院收治的100例急性脑梗死患者作为研究对象。根据治疗方法不同分为对照组和观察组,各50例。对照组给予依达拉奉右莰醇注射用浓溶液治疗,观察组给予依达拉奉右莰醇注射用浓溶液与氯吡格雷联合治疗,比较两组凝血功能指标、炎症因子、神经功能缺损与日常生活活动能力以及不良反应发生率。结果治疗后,观察组凝血功能指标均优于对照组,炎症因子水平低于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组美国国立卫生研究院卒中量表评分为(9.28±1.21)分,低于对照组的(12.57±1.40)分,差异有统计学意义(t=12.572,P<0.05)。研究组的Barthel指数评分为(83.50±3.89)分,高于对照组的(78.92±4.56)分,差异有统计学意义(t=5.403,P<0.05)。两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论依达拉奉与氯吡格雷联合治疗能够有效改善急性脑梗死患者的凝血功能、降低炎症因子水平,有助于提高神经功能恢复和日常生活活动能力,且不会增加不良反应。

Objective To investigate the effect of Edaravone combined with clopidogrel in the treatment of acute cerebral infarction.Methods A total of 100 patients with acute cerebral infarction admitted to Liaocheng Maternal and Child Health Hospital of Shandong Province from January 2022 to October 2023 were non-randomly selected as the research objects.According to different treatment methods,they were divided into control group and observation group,50 cases each.The control group was treated with edaravone dextra camphorol injection concentrated solution,and the observation group was treated with Edaravone dextra camphorol injection concentrated solution combined with clopidogrel.Coagulation function indexes,inflammatory factors,neurological impairment,activities of daily living and the incidence of adverse reactions were compared between the two groups.Results After treatment,the coagulation function indexes of the observation group were better than those of the control group,and the levels of inflammatory factors were lower than those of the control group,the differences were statistically significant(all P<0.05).After treatment,the National Institutes of Health Stroke Scale score of the observation group was 9.28±1.21,which was lower than 12.57±1.40 of the control group,and the difference was statistically significant(t=12.572,P<0.05).The Barthel index score in the study group was 83.50±3.89,higher than 78.92±4.56 of the control group,and the difference was statistically significant(t=5.403,P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Edaravone combined with clopidogrel can effectively improve the coagulation function and reduce the level of inflammatory factors in patients with acute cerebral infarction,and help to improve the recovery of neurological function and the ability of daily living activities without increasing adverse reactions.