血清CAR和PCT及IL-10水平对上尿路结石患者术后泌尿系统感染的预测价值

Predictive Value about Levels of Serum CAR,PCT,and IL-10 on Postoperative Urinary System Infection in Patients with Upper Urinary Tract Stones

目的:分析血清C反应蛋白(CRP)与清蛋白(ALB)的比值(CAR)、降钙素原(PCT)及白细胞介素-10(IL-10)水平对上尿路结石患者术后发生泌尿系统感染的预测价值。方法:回顾性分析石河子市人民医院2020年6月—2022年6月收治的100例上尿路结石患者的临床资料,根据术后是否发生泌尿系统感染将其分为感染组(n=26)与非感染组(n=74)。对上尿路结石患者术后发生泌尿系统感染的相关因素进行分析,采用Logistic回归分析其危险因素,采用受试者操作特征曲线(ROC)评估危险因素在术后发生泌尿系统感染中的预测价值。结果:单因素分析结果显示,合并其他慢性疾病,CAR、PCT、IL-10水平与上尿路结石患者术后发生泌尿系统感染相关(P<0.05);Logistic回归分析结果显示,CAR、PCT、IL-10水平上升是上尿路结石患者术后泌尿系统感染的危险因素(P<0.05);ROC曲线分析CAR、PCT、IL-10联合预测上尿路结石患者术后发生泌尿系统感染的ROC曲线下面积为0.995,灵敏度为95.90%,特异度为96.70%,均优于CAR、PCT、IL-10各指标单独预测(P<0.05)。结论:CAR、PCT、IL-10水平上升是上尿路结石患者术后泌尿系统感染的危险因素,对其具有较高的预测价值,且三者联合应用可有效提高应用效能。

Objective:To analyze the predictive value about levels of serum C-reactive protein(CRP)to albumin(ALB)ratio(CAR),procalcitonin(PCT)and interleukin-10(IL-10)on postoperative urinary system infection in patients with upper urinary tract stones.Methods:Clinical data of 100 patients with upper urinary tract stones admitted to Shihezi People's Hospital from June 2020 to June 2022 were retrospectively selected.Patients were divided into an infected group(n=26)and an uninfected group(n=74)based on whether they developed urinary system infection after surgery.The risk factors of postoperative urinary system infection in patients with upper urinary tract stones were analyzed by Logistic regression,and the predictive value of risk factors in postoperative urinary system infection was evaluated by receiver operating characteristic curve(ROC).Results:Univariate analysis showed that other chronic diseases,the levels of CAR,PCT,and IL-10 were associated with postoperative urinary system infection in patients with upper urinary tract stones(P<0.05).The results of Logistic regression analysis showed that high levels of CAR,PCT,and IL-10 were risk factors for postoperative urinary system infection in patients with upper urinary tract stones(P<0.05).ROC curve analysis combined with CAR,PCT and IL-10 predicted postoperative urinary system infection in patients with upper urinary tract stones with an area under the curve of 0.995,sensitivity of 95.90%and specificity of 96.70%,all of which were superior to the prediction of CAR,PCT and IL-10 alone.Conclusion:Hight levels of CAR,PCT,and IL-10 are risk factors for postoperative urinary system infection in patients with upper urinary tract stones,and they have high predictive value,and the combination of the three can effectively improve the efficacy.