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早期介入栓塞术对老年颅内动脉瘤患者的治疗效果分析

Effect Analgsis of Early Interventional Embolization on Elderly Patients with Intracranial Aneurysms
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摘要 目的:分析早期介入栓塞术治疗老年颅内动脉瘤患者的临床效果。方法:选择2020年6月—2023年8月枣庄市峄城区人民医院收治的98例老年颅内动脉瘤患者为研究对象,以密闭信封法将其分为对照组和研究组,各49例。对照组采用开颅夹闭术治疗,研究组采用早期介入栓塞术治疗。比较两组术前及术后1个月的血清指标、神经功能及并发症发生情况。结果:术后1个月,研究组基质金属蛋白酶-9为(94.67±7.53)ng/mL,神经元特异性烯醇化酶为(20.65±4.28)μg/L,均低于对照组的(98.35±7.61)ng/mL、(24.91±4.62)μg/L,研究组血管内皮生长因子为(451.96±33.72)μg/L,高于对照组的(412.57±33.84)μg/L,差异均有统计学意义(P<0.05)。术后1个月,研究组神经功能缺损评分低于对照组,差异有统计学意义(P<0.05)。研究组并发症发生率为4.08%,低于对照组的16.33%,差异有统计学意义(P<0.05)。结论:老年颅内动脉瘤患者采用早期介入栓塞术治疗,可改善脑组织微循环障碍,有助于减轻脑神经功能损伤,且具有一定安全性。 Objective:To analyze the clinical efficacy of early interventional embolization in elderly patients with intracranial aneurysm.Methods:A total of 98 intracranial aneurysm patients with intracranial aneurysm treated in Yicheng District People’s Hospital of Zaozhuang City from June 2020 to August 2023 were selected as the study objects,and divided into a control group and a study group with 49 cases in each group by sealed envelope method.The control group was treated with craniotomy and the study group was treated with early interventional embolization.The serum indexes,neurological function and complications of the two groups were compared before and one month after surgery.Results:One month after surgery,the matrix metalloproteinase-9 of the study group was(94.67±7.53)ng/mL,neuron-specific enolase was(20.65±4.28)μg/L,which were lower than(98.35±7.61)ng/mL and(24.91±4.62)μg/L of the control group,the vascular endothelial growth factor of the study group was(451.96±33.72)μg/L,which was higher than(412.57±33.84)μg/L of the control group,the differences were statistically significant(P<0.05).One month after operation,the neurological impairment score of the study group was lower than that of the control group,the difference was statistically significant(P<0.05).The complication rate of the study group was 4.08%,which was lower than 16.33%of the control group,the difference was statistically significant(P<0.05).Conclusion:Early interventional embolization in elderly patients with intracranial aneurysms can improve the microcirculation disorder of brain tissue,help to reduce the damage of cerebral nerve function,and has certain safety.
作者 郭金龙 狄超 GUO Jinlong;DI Chao(Department of Neurosurgery,Yicheng District People’s Hospital of Zaozhuang City,Zaozhuang 277300,China;Department of Neurosurgery,Zaozhuang Municipal Hospital of Shandong Province,Zaozhuang 277100,China)
出处 《中国伤残医学》 2024年第17期23-25,共3页 Chinese Journal of Trauma and Disability Medicine
关键词 颅内动脉瘤 介入栓塞术 脑神经功能 并发症 血清指标 术后康复 Intracranial aneurysms Interventional embolization Cranial nerve function Complications Serum index Postoperative rehabilitation
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